The hexosamine biosynthesis pathway (HBP) produces uridine diphosphate-N-acetyl
glucosamine, UDP-GlcNAc, which is a key metabolite that is used for N-or O-linked …

The biosynthesis of bacterial cell wall peptidoglycan is a complex process that involves
enzyme reactions that take place in the cytoplasm (synthesis of the nucleotide precursors) …

Enzymes are very efficient catalysts that are essential for the functioning of living organisms.
The low efficiency of biocatalysts produced de novo relative to those that have evolved …

Sporothrix schenckii, now named the S. schenckii species complex, has largely been known
as the etiological agent of sporotrichosis, which is an acute or chronic subcutaneous …

Many enzymes contain tunnels and gates that are essential to their function. Gates
reversibly switch between open and closed conformations and thereby control the traffic of …

Bacterial microcompartment (MCP) organelles are cytosolic, polyhedral structures consisting
of a thin protein shell and a series of encapsulated, sequentially acting enzymes. To date …

l-Glutamine: d-fructose-6-phosphate amidotransferase, also known as glucosamine-6-
phosphate synthase (GlcN6P synthase), which catalyzes the first step in a pathway leading …

Glucosamine-6-phosphate synthase (GlmS) channels ammonia from glutamine at the
glutaminase site to fructose 6-phosphate (Fru6P) at the synthase site. Escherichia coli GlmS …

The hexosamine pathway (HP) is a key anabolic pathway whose product uridine 5'-
diphospho-N-acetyl-D-glucosamine (UDP-GlcNAc) is an essential precursor for …

Enzymes exhibit a high degree of specificity for the reactions they catalyze and the
substrates involved in these reactions. The eminent specificity of enzymes inspired the …