Oral bioavailability of bioactive compounds; modulating factors, in vitro analysis methods, and enhancing strategies
Foods are complex biosystems made up of a wide variety of compounds. Some of them,
such as nutrients and bioactive compounds (bioactives), contribute to supporting body …
such as nutrients and bioactive compounds (bioactives), contribute to supporting body …
Nanocoating of lactic acid bacteria: Properties, protection mechanisms, and future trends
Q Fan, X Zeng, Z Wu, Y Guo, Q Du, M Tu… - Critical Reviews in …, 2024 - Taylor & Francis
Lactic acid bacteria (LAB) is a type of probiotic that may benefit intestinal health. Recent
advances in nanoencapsulation provide an effective strategy to protect them from harsh …
advances in nanoencapsulation provide an effective strategy to protect them from harsh …
Magnetically driven capsules with multimodal response and multifunctionality for biomedical applications
Untethered capsules hold clinical potential for the diagnosis and treatment of
gastrointestinal diseases. Although considerable progress has been achieved recently in …
gastrointestinal diseases. Although considerable progress has been achieved recently in …
Formation mechanism of yeast-soy protein extrudates during high-moisture extrusion and their digestive properties
Yeast protein (YP) has generated significant interest due to its potential for high production
efficiency and nutritional value. This study investigated the effects of YP ratios (0–50%) on …
efficiency and nutritional value. This study investigated the effects of YP ratios (0–50%) on …
Paracellular delivery of protein drugs with smart enteropatho nanoparticles
I Ramirez-Velez, AA Namjoshi, UM Effiong… - ACS …, 2024 - ACS Publications
A general platform for the safe and effective oral delivery of biologics would revolutionize the
administration of protein-based drugs, improving access for patients and lowering the …
administration of protein-based drugs, improving access for patients and lowering the …
An in vitro protocol to characterise the resistance of food proteins to intestinal digestion
K Wang, RWR Crevel, ENC Mills - Food and Chemical Toxicology, 2023 - Elsevier
In vitro digestion tests provide data on the form in which dietary proteins maybe presented to
the gut mucosal immune system, one of many strands of evidence used in allergenicity risk …
the gut mucosal immune system, one of many strands of evidence used in allergenicity risk …
Comparing gastric emptying of cellulose nanocrystals with sodium alginate and pectin using a dynamic in vitro stomach model
Cellulose nanocrystals (CNC) are increasingly recognized for their potential in various
applications, including packaging, cosmetics, and biomedical engineering. Due to their …
applications, including packaging, cosmetics, and biomedical engineering. Due to their …
Assessment of food effects during clinical development
Food-drug interactions frequently hamper oral drug development due to various
physicochemical, physiological and formulation-dependent mechanisms. This has …
physicochemical, physiological and formulation-dependent mechanisms. This has …
A Rational approach to predicting immediate release formulation behavior in multiple gastric motility patterns: a combination of a biorelevant apparatus, design of …
Gastric mechanical stress often impacts drug dissolution from solid oral dosage forms, but in
vitro experiments cannot recreate the substantial variability of gastric motility in a reasonable …
vitro experiments cannot recreate the substantial variability of gastric motility in a reasonable …
Predicting intestinal effective permeability of different transport mechanisms: Comparing ex vivo porcine and in vitro dialysis models
Intestinal effective permeability (P eff) is among the most critical parameters that determine
the bioavailability of nutrients. Rats have been widely used to estimate the P eff of bioactive …
the bioavailability of nutrients. Rats have been widely used to estimate the P eff of bioactive …