Microvascular integrity is a critical factor in myocardial fluid homeostasis. The subtle
equilibrium between capillary filtration and lymphatic fluid removal is disturbed during …

Abstract Sodium–glucose cotransporter 2 (SGLT2) inhibitors were initially developed for
their glucose-lowering effects and have shown a modest glycaemic benefit in people with …

Importance Sodium-glucose cotransporter 2 (SGLT-2) inhibitors improve outcomes in
patients with type 2 diabetes, heart failure, and chronic kidney disease, but their effect on …

Aims Lower respiratory tract infections (LRTI) are common worldwide. Patients with heart
failure and mildly reduced or preserved ejection fraction (HFmrEF/HFpEF) have a high risk …

Endothelin A and B receptors, together with sodium-glucose cotransporter-2 (SGLT-2)
channels are important targets in improving endothelial function and intervention with …

Objective SGLT-2i are increasingly recognized for their benefits in patients with
cardiometabolic risk factors. Additionally, emerging evidence suggests potential applications …

Background: Molnupiravir and nirmatrelvir-ritonavir (Paxlovid) are oral antivirals that have
been proposed as treatments for patients admitted to hospital with COVID-19. Methods: In …

Soon after the onset of the COVID-19 pandemic, it became apparent that diabetes, obesity,
hypertension, underlying cardiovascular, and kidney diseases were associated with an …

Over 850 million people worldwide have chronic kidney disease (CKD), which is projected
to become the fifth global cause of death by 2040 [1]. However, awareness of the concept of …

Background: Several studies have reported a reduced risk of COVID-19-related mortality in
patients taking antidiabetic medications. This is an umbrella review, meta-analysis, and …