White matter abnormalities across the lifespan of schizophrenia: a harmonized multi-site diffusion MRI study
Several prominent theories of schizophrenia suggest that structural white matter pathologies
may follow a developmental, maturational, and/or degenerative process. However, a lack of …
may follow a developmental, maturational, and/or degenerative process. However, a lack of …
The role of glial cells in mental illness: a systematic review on astroglia and microglia as potential players in schizophrenia and its cognitive and emotional aspects
D Laricchiuta, M Papi, D Decandia… - Frontiers in Cellular …, 2024 - frontiersin.org
Schizophrenia is a complex and severe mental disorder that affects approximately 1% of the
global population. It is characterized by a wide range of symptoms, including delusions …
global population. It is characterized by a wide range of symptoms, including delusions …
[HTML][HTML] Inflammatory subgroups of schizophrenia and their association with brain structure: A semi-supervised machine learning examination of heterogeneity
Objective Immune system dysfunction is hypothesised to contribute to structural brain
changes through aberrant synaptic pruning in schizophrenia. However, evidence is mixed …
changes through aberrant synaptic pruning in schizophrenia. However, evidence is mixed …
Individual deviations from normative models of brain structure in a large cross-sectional schizophrenia cohort
The heterogeneity of schizophrenia has defied efforts to derive reproducible and definitive
anatomical maps of structural brain changes associated with the disorder. We aimed to map …
anatomical maps of structural brain changes associated with the disorder. We aimed to map …
Accelerated gray and white matter deterioration with age in schizophrenia
VL Cropley, P Klauser, RK Lenroot… - American Journal of …, 2017 - Am Psychiatric Assoc
Objective: Although brain changes in schizophrenia have been proposed to mirror those
found with advancing age, the trajectory of gray matter and white matter changes during the …
found with advancing age, the trajectory of gray matter and white matter changes during the …
Cell type-specific manifestations of cortical thickness heterogeneity in schizophrenia
Brain morphology differs markedly between individuals with schizophrenia, but the cellular
and genetic basis of this heterogeneity is poorly understood. Here, we sought to determine …
and genetic basis of this heterogeneity is poorly understood. Here, we sought to determine …
Regional, circuit and network heterogeneity of brain abnormalities in psychiatric disorders
The substantial individual heterogeneity that characterizes people with mental illness is
often ignored by classical case–control research, which relies on group mean comparisons …
often ignored by classical case–control research, which relies on group mean comparisons …
Imprinted DLK1-DIO3 region of 14q32 defines a schizophrenia-associated miRNA signature in peripheral blood mononuclear cells
MicroRNAs (miRNAs) regulate gene expression at the post-transcriptional level and are
important for coordinating nervous system development and neuronal function in the mature …
important for coordinating nervous system development and neuronal function in the mature …
Genetic estimates of correlation and causality between blood-based biomarkers and psychiatric disorders
There is a long-standing interest in exploring the relationship between blood-based
biomarkers and psychiatric disorders, despite their causal role being difficult to resolve in …
biomarkers and psychiatric disorders, despite their causal role being difficult to resolve in …
White matter disruptions in schizophrenia are spatially widespread and topologically converge on brain network hubs
White matter abnormalities associated with schizophrenia have been widely reported,
although the consistency of findings across studies is moderate. In this study, neuroimaging …
although the consistency of findings across studies is moderate. In this study, neuroimaging …