The dual leucine zipper kinase (DLK) alias mitogen-activated protein 3 kinase 12
(MAP3K12) has gained much attention in recent years. DLK belongs to the mixed lineage …

An ever-growing number of studies highlight the importance of S-acylation, a reversible
protein-lipid modification, for diverse aspects of intracellular signaling. In this review, we …

Genetic and pharmacological perturbation of the cytoskeleton enhances the regenerative
potential of neurons. This response requires Dual-leucine Zipper Kinase (DLK), a neuronal …

Sterile alpha and TIR motif containing 1 (SARM1) is an inducible NADase that localizes to
mitochondria throughout neurons and senses metabolic changes that occur after injury …

Dual leucine zipper kinase (DLK) mediates multiple neuronal stress responses, and its
expression levels are constantly suppressed to prevent excessive stress signaling. We …

Primary cilia are specialized organelles supporting the development and function of cells
and organisms. Intraflagellar transport (IFT) is essential for cilia formation, maintenance, and …

Neurons establish functional connections responsible for how we perceive and react to the
world around us. Communication from a neuron to its target cell occurs through a long …

The evolutionarily conserved Notch signaling pathway controls cell–cell communication,
enacting cell fate decisions during development and tissue homeostasis. Its dysregulation is …

Currently there are no effective treatments for an array of neurodegenerative disorders to a
large part because cell-based models fail to recapitulate disease. Here we developed a …

Abstract The conserved MAP3K12/Dual Leucine Zipper Kinase (DLK) plays versatile roles in
neuronal development, axon injury and stress responses, and neurodegeneration …