Cholinesterase inhibitors as Alzheimer's therapeutics

K Sharma - Molecular medicine reports, 2019 - spandidos-publications.com
Alzheimer's disease (AD) is one of the most common forms of dementia. AD is a chronic
syndrome of the central nervous system that causes a decline in cognitive function and …

The state of the art on acetylcholinesterase inhibitors in the treatment of Alzheimer's disease

I Vecchio, L Sorrentino, A Paoletti… - Journal of Central …, 2021 - journals.sagepub.com
Alzheimer's disease (AD) is a chronic disabling disease that affects the central nervous
system. The main consequences of AD include the decline of cognitive functions and …

Alzheimer's disease pharmacotherapy in relation to cholinergic system involvement

GD Stanciu, A Luca, RN Rusu, V Bild… - Biomolecules, 2019 - mdpi.com
Alzheimer's disease, a major and increasing global health challenge, is an irreversible,
progressive form of dementia, associated with an ongoing decline of brain functioning. The …

New Acetylcholinesterase Inhibitors for Alzheimer′ s Disease

M Mehta, A Adem, M Sabbagh - International Journal of …, 2012 - Wiley Online Library
Acetylcholinesterase (AChE) remains a highly viable target for the symptomatic
improvement in Alzheimer′ s disease (AD) because cholinergic deficit is a consistent and …

Natural products as a source of Alzheimer's drug leads

P Williams, A Sorribas, MJR Howes - Natural product reports, 2011 - pubs.rsc.org
Covering: up to 2010 This review focuses on recent developments in the use of natural
products as therapeutics for Alzheimer's disease. The compounds span a diverse array of …

Acetylcholinesterase inhibitors as Alzheimer therapy: from nerve toxins to neuroprotection

M Singh, M Kaur, H Kukreja, R Chugh, O Silakari… - European journal of …, 2013 - Elsevier
Acetylcholinesterase is a member of the α/β hydrolase protein super family, with a significant
role in acetylcholine-mediated neurotransmission. Research in the modulators of AChEs …

Cholinesterase targeting by polyphenols: A therapeutic approach for the treatment of Alzheimer's disease

NR Jabir, FR Khan, S Tabrez - CNS neuroscience & …, 2018 - Wiley Online Library
Alzheimer's disease (AD) is a progressive irreversible neurodegenerative disorder
characterized by excessive deposition of β‐amyloid (Aβ) oligomers, and neurofibrillary …

The main active constituents and detoxification process of Ginkgo biloba seeds and their potential use in functional health foods

HY Wang, YQ Zhang - Journal of Food Composition and Analysis, 2019 - Elsevier
Ginkgo biloba leaves and seeds have been used as a food and traditional herbal remedies
for thousands of years. Extracts from G. biloba leaves, especially EGb761, have been …

Metabolic and biotransformation effects on dietary glucosinolates, their bioavailability, catabolism and biological effects in different organisms

ZT Shakour, NG Shehab, AS Gomaa… - Biotechnology …, 2022 - Elsevier
Glucosinolate-producing plants have long been recognized for both their distinctive benefits
to human nutrition and their resistance traits against pathogens and herbivores. Despite the …

Cardanol-derived AChE inhibitors: Towards the development of dual binding derivatives for Alzheimer's disease

LFN Lemes, G de Andrade Ramos… - European Journal of …, 2016 - Elsevier
Cardanol is a phenolic lipid component of cashew nut shell liquid (CNSL), obtained as the
byproduct of cashew nut food processing. Being a waste product, it has attracted much …