Emerging target discovery and drug repurposing opportunities in chordoma

DM Freed, J Sommer, N Punturi - Frontiers in Oncology, 2022 - frontiersin.org
The development of effective and personalized treatment options for patients with rare
cancers like chordoma is hampered by numerous challenges. Biomarker-guided …

Chordoma cells possess bone-dissolving activity at the bone invasion front

K Kawaai, Y Oishi, Y Kuroda, R Tamura, M Toda… - Cellular Oncology, 2024 - Springer
Purpose Chordomas are malignant tumors that destroy bones, compress surrounding nerve
tissues and exhibit phenotypes that recapitulate notochordal differentiation in the axial …

Genetic murine models of spinal development and degeneration provide valuable insights into intervertebral disc pathobiology.

J Melrose, S Tessier, MV Risbud - 2021 - jdc.jefferson.edu
Disc degeneration and associated back and neck pain elicits a substantial burden on
healthcare systems and the individuals affected, necessitating the development of novel …

Notochordal Tumors

S Kaur, VC Pullicino, R Lalam - Imaging of Primary Tumors of the Osseous …, 2023 - Springer
Notochordal tumors comprise a spectrum of tumors arising in the axial skeleton having
notochordal differentiation characterized by the co-expression of cytokeratin and brachyury …

A rare case of chordoma presenting as a Pancoast tumor

PT Sobash, K Vedala, D Alfano… - Rare …, 2021 - journals.sagepub.com
The notochord is the defining structure of all chordate embryos. It is a midline structure
ventral to the ectoderm, neural plates, and neural arch. Remnants of the notochord …

An experience in treatment of neurologically silent clival chordoma mimicking a nasopharyngeal tumor

JT Lin, HJ Hsu - Ear, Nose & Throat Journal, 2024 - journals.sagepub.com
Cranial chordoma is a rare neoplasm that is challenging to both diagnose and manage. We
present our experience in treating a case of clival chordoma mimicking a nasopharyngeal …

Miscellaneous Skull Base Tumors

JM Das - Neuro-Oncology Explained Through Multiple Choice …, 2023 - Springer
This chapter is on miscellaneous skull base tumors including chordomas, chordosarcomas,
glomus tumors, and esthesioneuroblastomas. Here, we concentrate on the different …

Articulaciones

C Santamaría Martín, ME Diessler… - Libros de …, 2022 - sedici.unlp.edu.ar
Una definición de articulación, que contempla aspectos histológicos, es aquella que postula
a la articulación como un conjunto de diversas variedades de tejido conectivo que ponen en …

[PDF][PDF] Fractionated Stereotactic Radiotherapy in Recurrent Clival Chordoma: A

RA Sunil, L Viswanath - researchgate.net
Clival chordomas are a rare type of clinically malignant tumour, arising from the
undifferentiated remnants of the notochord, which are slow-growing, usually radioresistant …