Infections with flaviviruses, such as dengue, West Nile virus and the recently re-emerging
Zika virus, are an increasing and probably lasting global risk. This Review summarizes and …

Dengue viruses (DENVs) cause the most common arthropod-borne viral disease in man
with 50–100 million infections per year. Because of the lack of a vaccine and antiviral drugs …

This review examines the organization and translocation of Flavivirus genome RNA,
proteolytic processing of the viral polyprotein, properties of the structural and nonstructural …

Dengue, a major public health problem throughout subtropical and tropical regions, is an
acute infectious disease characterized by biphasic fever, headache, pain in various parts of …

The major medical importance of flaviviruses has fostered studies into their molecular
biology in research laboratories around the world. Although the molecular biology of …

Because of its stringent sequence specificity, the catalytic domain of the nuclear inclusion
protease from tobacco etch virus (TEV) is a useful reagent for cleaving genetically …

Although they are often exploited to facilitate the expression and purification of recombinant
proteins, every affinity tag, whether large or small, has the potential to interfere with the …

Despite the rapid mutational change that is typical of positive-strand RNA viruses, enzymes
mediating the replication and expression of virus genomes contain arrays of conserved …

The cleavages at the junctions of the flavivirus nonstructural (NS) proteins NS2A/NS2B,
NS2B/NS3, NS3/NS4A, and NS4B/NS5 share an amino acid sequence motif and are …

Publisher Summary This chapter examines families of serine peptidases. Serine peptidases
are found in viruses, bacteria, and eukaryotes. They include exopeptidases …