The activity-dependent trafficking of AMPA receptors (AMPAR) mediates synaptic strength
and plasticity, while the perturbed trafficking of the receptors of different subunit …

Pyruvate dehydrogenase kinases (PDK1–4) are mitochondrial metabolic regulators that
serve as decision makers via modulation of pyruvate dehydrogenase (PDH) activity to …

Purpose: To explore the potential mechanisms of glutamate and its receptors in stress-
induced hyperalgesia. Materials and methods: The stress-induced hyperalgesia, glutamate …

Background Proinflammatory cytokine interleukin-1β (IL-1β) released from spinal microglia
plays an important role in the maintenance of acute and chronic pain states. However, the …

Abstract Lipocalin-2 (LCN2) is an acute phase protein induced in response to injury,
infection or other inflammatory stimuli. Based on the previously reported involvement of …

The dorsal horn (DH) neurons of the spinal cord play a critical role in nociceptive input
integration and processing in the central nervous system. Engaged neuronal classes and …

Objectives: Despite the interest in scientific community, there is still poor evidence about
pulsed radiofrequency (PRF) efficacy in the treatment of neuropathic pain. In order to …

The A-kinase anchoring protein 150 (AKAP150) organizes kinases and phosphatases to
regulate AMPA receptors (AMPARs) that are pivotal for synaptic plasticity. AKAP150 itself …

In the spinal cord, glutamate serves as the primary excitatory neurotransmitter. Monitoring
spinal glutamate concentrations offers valuable insights into spinal neural processing …

Many patients with systemic lupus erythematosus (SLE) live with chronic pain despite
advances in medical management in reducing mortality related to SLE. Few animal studies …