Vestibular hair cells and afferents: two channels for head motion signals
RA Eatock, JE Songer - Annual review of neuroscience, 2011 - annualreviews.org
Vestibular epithelia of the inner ear detect head motions over a wide range of amplitudes
and frequencies. In mammals, afferent nerve fibers from central and peripheral zones of …
and frequencies. In mammals, afferent nerve fibers from central and peripheral zones of …
Age-related hearing loss pertaining to potassium ion channels in the cochlea and auditory pathway
B Peixoto Pinheiro, B Vona, H Löwenheim… - … -European Journal of …, 2021 - Springer
Age-related hearing loss (ARHL) is the most prevalent sensory deficit in the elderly and
constitutes the third highest risk factor for dementia. Lifetime noise exposure, genetic …
constitutes the third highest risk factor for dementia. Lifetime noise exposure, genetic …
Functional development of mechanosensitive hair cells in stem cell-derived organoids parallels native vestibular hair cells
XP Liu, KR Koehler, AM Mikosz, E Hashino… - Nature …, 2016 - nature.com
Inner ear sensory epithelia contain mechanosensitive hair cells that transmit information to
the brain through innervation with bipolar neurons. Mammalian hair cells do not regenerate …
the brain through innervation with bipolar neurons. Mammalian hair cells do not regenerate …
The potassium channel subunit KV1. 8 (Kcna10) is essential for the distinctive outwardly rectifying conductances of type I and II vestibular hair cells
In amniotes, head motions and tilt are detected by two types of vestibular hair cells (HCs)
with strikingly different morphology and physiology. Mature type I HCs express a large and …
with strikingly different morphology and physiology. Mature type I HCs express a large and …
Function and dysfunction of TMC channels in inner ear hair cells
The TMC1 channel was identified as a protein essential for hearing in mouse and human,
and recognized as one of a family of eight such proteins in mammals. The TMC family is part …
and recognized as one of a family of eight such proteins in mammals. The TMC family is part …
Kv7 channels and excitability disorders
F Jones, N Gamper, H Gao - Pharmacology of Potassium Channels, 2021 - Springer
Abstract Kv7. 1-Kv7. 5 (KCNQ1–5) K+ channels are voltage-gated K+ channels with major
roles in neurons, muscle cells and epithelia where they underlie physiologically important …
roles in neurons, muscle cells and epithelia where they underlie physiologically important …
A potassium channel agonist protects hearing function and promotes outer hair cell survival in a mouse model for age-related hearing loss
B Peixoto Pinheiro, M Müller, M Bös, J Guezguez… - Cell Death & …, 2022 - nature.com
Age-related hearing loss (ARHL) is the most common sensory impairment mainly caused by
degeneration of sensory hair cells in the cochlea with no causal medical treatment available …
degeneration of sensory hair cells in the cochlea with no causal medical treatment available …
Channeling your inner ear potassium: K+ channels in vestibular hair cells
FL Meredith, KJ Rennie - Hearing research, 2016 - Elsevier
During development of vestibular hair cells, K+ conductances are acquired in a specific
pattern. Functionally mature vestibular hair cells express different complements of K+ …
pattern. Functionally mature vestibular hair cells express different complements of K+ …
HCN channels expressed in the inner ear are necessary for normal balance function
GC Horwitz, JR Risner-Janiczek… - Journal of …, 2011 - Soc Neuroscience
HCN1–4 subunits form Na+/K+-permeable ion channels that are activated by
hyperpolarization and carry the current known as I h. I h has been characterized in vestibular …
hyperpolarization and carry the current known as I h. I h has been characterized in vestibular …
Rare KCNQ4 variants found in public databases underlie impaired channel activity that may contribute to hearing impairment
KCNQ4 is frequently mutated in autosomal dominant non-syndromic hearing loss (NSHL), a
typically late-onset, initially high-frequency loss that progresses over time (DFNA2). Most …
typically late-onset, initially high-frequency loss that progresses over time (DFNA2). Most …