The oral administration of therapeutic peptides and proteins is favoured from a patient and
commercial point of view. In order to reach the systemic circulation after oral administration …

Many active pharmaceutical ingredients (APIs) exhibit poor solubility and low dissolution
rates in aqueous environments such as the luminal fluids of the gastrointestinal tract. The …

A significant proportion of recently approved drug molecules possess poor aqueous
solubility which further restrains their desired bioavailability. Poor aqueous solubility of these …

Hot-melt extrusion (HME) has emerged as a pioneering manufacturing technology for
pharmaceutical industries, and the utilization is overgrowing due to its unit operation, cost …

Interest in 3D-printing technologies for pharmaceutical manufacturing of oral dosage forms
is driven by the need for personalized medicines. Most research to date has focused on …

Pharmaceutical formulation of oral dosage forms is continuously challenged by the low
solubility of new drug candidates. Pickering emulsions, emulsions stabilized with solid …

Many viruses, bacteria, and parasites rely on the lymphatic system for survival, replication,
and dissemination. While conventional anti-infectives can combat infection-causing agents …

Self-emulsifying drug delivery systems (ie SEDDS, SMEDDS and SNEDDS) are widely
employed as solubility and bioavailability enhancing formulation strategies for poorly water …

Mucus is a dynamic barrier which covers and protects the underlying mucosal epithelial
membrane against bacteria and foreign particles. This protection mechanism extends to …

Bacterial infections are an imminent global healthcare threat evolving from rapidly
advancing bacterial defence mechanisms that antibiotics fail to overcome. Antibiotics have …