Understanding the Role of miR-29a in the Regulation of RAG1, a Gene Associated with the Development of the Immune System
U Roy, SS Desai, S Kumari, T Bushra… - The Journal of …, 2024 - journals.aai.org
The process of Ag receptor diversity is initiated by RAGs consisting of RAG1 and RAG2 in
developing lymphocytes. Besides its role as a sequence-specific nuclease during V (D) J …
developing lymphocytes. Besides its role as a sequence-specific nuclease during V (D) J …
The bisulfite reaction with cytosine and genomic DNA structure
SS Smith - Analytical Biochemistry, 2024 - Elsevier
The bisulfite reaction with native DNA has been extensively employed in the detection of
non-B DNA structures that can form spontaneously in DNA. These sequences are dynamic …
non-B DNA structures that can form spontaneously in DNA. These sequences are dynamic …
Dysregulation of R-loop homeostasis shapes the immunosuppressive microenvironment and induces malignant progression in melanoma
Y Ouyang, Y Gu, S Li, X Wei, Y Liu, Z Wang, F Tang… - Apoptosis, 2024 - Springer
Dysregulated R-loop homeostasis leads to DNA replication stress and genomic instability, a
major driver of cancer. However, the role of R-loops in melanoma development remains …
major driver of cancer. However, the role of R-loops in melanoma development remains …
Mutations at BCL11B Exon 4 Associated with T Cell Acute Lymphoblastic Leukemia Are Facilitated by AID and Formation of Non-B DNA Conformations
One of the primary reasons behind the pathogenesis of T cell acute lymphoblastic leukemia
(T-ALL) is the deregulation of the transcription factor BCL11B. The exon 4 of BCL11B …
(T-ALL) is the deregulation of the transcription factor BCL11B. The exon 4 of BCL11B …
Motive and Opportunity: MYC rearrangements in high-grade B-cell lymphoma with MYC and BCL2 rearrangements-an LLMPP study
Rearrangements that place the oncogenes MYC, BCL2, or BCL6 adjacent to
superenhancers are common in mature B-cell lymphomas. Lymphomas with diffuse large B …
superenhancers are common in mature B-cell lymphomas. Lymphomas with diffuse large B …
Alternative DNA structures in hematopoiesis and adaptive immunity.
Besides the canonical B-form, DNA also adopts alternative non-B form conformations which
are highly conserved in all domains of life. While extensive research over decades has …
are highly conserved in all domains of life. While extensive research over decades has …