Calcineurin is a eukaryotic Ca2+-and calmodulin-dependent serine/threonine protein
phosphatase. It is a heterodimeric protein consisting of a catalytic subunit calcineurin A …

Reactive oxygen species are produced by all aerobic cells and are widely believed to play a
pivotal role in aging as well as a number of degenerative diseases. The consequences of …

Introduction 3. Reactive oxygen species in tumor growth and cellular survival 4. Reactive
oxygen species in cell motility and metastasis formation 5. Generation of reactive oxygen …

Ligand-receptor interactions can generate the production of hydrogen peroxide (H2O2) in
cells, the implications of which are becoming appreciated. Fluctuations in H2O2 levels can …

Excessive or aberrant generation of neutrophil extracellular traps (NETs) has recently
become implicated in the underlying aetiology of a number of human pathologies including …

The multifunctional Ca2+-and calmodulin-dependent protein kinase II (CaMKII) is now
recognized to play a central role in pathological events in the cardiovascular system. CaMKII …

■ Abstract Although eosinophilic airway inflammation is recognized as an important feature
of some patients with chronic, stable asthma, evidence supports an important role for …

Oxidizing agents are powerful activators of factors responsible for the transcriptional
activation of cytokine-encoding genes involved in tissue injury. In this study we show …

As spermatozoa mature within the epididymis they acquire the potential for capacitation and
ultimately fertilization. In biochemical terms, the former is reflected in the progressive …

OBJECTIVE We and others have reported the use of tacrolimus in refractory inflammatory
bowel disease (IBD). Little is known about its long-term efficacy and safety. METHODS In …