The biological activity of Mannich bases, a structurally heterogeneous class of chemical
compounds that are generated from various substrates through the introduction of an …

Pyronaridine was synthesized in 1970 at the Institute of Chinese Parasitic Disease and has
been used in China for over 30 years for the treatment of malaria. Pyronaridine has high …

Pyronaridine (PYR) is an erythrocytic schizonticide with a potent antimalarial activity against
multidrug‐resistant Plasmodium. The drug is used in combination with artesunate for the …

Pyronaridine-artesunate was recently strongly recommended in the 2022 update of the
WHO Guidelines for the Treatment of Malaria, becoming the newest artemisinin-based …

Rheumatoid arthritis (RA), a chronic systemic autoimmune disease, stimulates various
immune cells especially macrophages, causing release of various proinflammatory …

The n-octanol/water partition coefficients of propranolol and atenolol were experimentally
determined by ultraviolet (UV) spectroscopy at T=(298.15, 310.15 and 314.15) K. All …

We have recently identified three molecules (tilorone, quinacrine and pyronaridine
tetraphosphate) which all demonstrated efficacy in the mouse model of infection with mouse …

Aim We tested the utility of topical application of Chloroquine-Solid Lipid Nanoparticle
loaded gel against rheumatoid arthritis using Complete Freund's adjuvant (CFA) induced …

The UV-vis spectra of isocorydine 1, norisocorydine 2 and boldine 3 were studied in 2% v/v
acetonitrile, at constant ionic strength (0.1 M NaCl, 35 degree Celsius). The p K a values of …

Antimalarial drugs commonly referred to as antimalarials, include a variety of compounds
with different physicochemical properties. There is a lack of information on antimalarial …