BACKGROUND Tertiary lymphoid structures (TLSs) are organized aggregates of immune
cells that form postnatally in nonlymphoid tissues. TLSs are not found under physiological …

The tumor microenvironment (TME) is a heterogeneous, complex organization composed of
tumor, stroma, and endothelial cells that is characterized by cross talk between tumor and …

Tertiary lymphoid structures (TLSs) are ectopic lymphoid organs that develop in non-
lymphoid tissues at sites of chronic inflammation including tumours. Key common …

Cell therapy practices date back to the 19th century and continue to expand on
investigational and investment grounds. Cell therapy includes stem cell-and non–stem cell …

Breast cancer is a heterogeneous disease. Tumor cells and associated healthy cells form
ecosystems that determine disease progression and response to therapy. To characterize …

We previously demonstrated that tumor-infiltrating lymphocytes (TIL) in human breast cancer
sometimes form organized tertiary lymphoid structures (TLS) characterized by CXCL13 …

Assessment of tumor-infiltrating lymphocytes (TILs) in histopathologic specimens can
provide important prognostic information in diverse solid tumor types, and may also be of …

Tumor-infiltrating B cells (TIL-B) in breast cancer (BC) have previously been associated with
improved clinical outcomes; however, their roles in tumor immunity are not currently well …

Type I interferons (IFN-Is) are emerging as key drivers of inflammation and
immunosuppression in chronic infection. Control of these infections requires IFN-I signaling; …

Although common evolutionary principles drive the growth of cancer cells regardless of the
tissue of origin, the microenvironment in which tumours arise substantially differs across …