Although the biological functions of cell and tissue can be regulated by biochemical factors
(eg, growth factors, hormones), the biophysical effects of materials on the regulation of …

A diverse array of environmental factors contributes to the overall control of stem cell activity.
In particular, new data continue to mount on the influence of the extracellular matrix (ECM) …

Cells in their in vivo microenvironment constantly encounter and respond to a multitude of
signals. While the role of biochemical signals has long been appreciated, the importance of …

Millions of people lose or damage their organs or tissues due to disease, birth defects, or
accidents each year. Stem cells, such as embryonic stem cells (ESCs), induced pluripotent …

Tendon is a specific connective tissue composed of parallel collagen fibers. The effect of this
tissue-specific matrix orientation on stem cell differentiation has not been investigated. This …

Neural tissue repair and regeneration strategies have received a great deal of attention
because it directly affects the quality of the patient's life. There are many scientific challenges …

Neural stem/progenitor cells (NSCs) are capable of self-renewal and differentiation into all
types of neural lineage under different biochemical and topographical cues. In this study, we …

Human tissues are intricate ensembles of multiple cell types embedded in complex and well-
defined structures of the extracellular matrix (ECM). The organization of ECM is frequently …

In the body, cells encounter a complex milieu of signals, including topographical cues, in the
form of the physical features of their surrounding environment. Imposed topography can …

Unlike other tissue types, the nervous tissue extends to a wide and complex environment
that provides a plurality of different biochemical and topological stimuli, which in turn defines …