Galectins are soluble glycan-binding proteins that interact with a wide range of glycoproteins
and glycolipids and modulate a broad spectrum of physiological and pathological …

Cardiac inflammation and fibrosis are central pathogenic mechanisms leading to heart
failure. Transplantation is still the treatment of choice for many patients undergoing end …

Galectins (Gals), a family of multifunctional glycan-binding proteins, have been traditionally
defined as β-galactoside binding lectins. However, certain members of this family have …

Galectins, a family of glycan-binding proteins have been shown to bind a wide range of
glycans. In the cytoplasm, these glycans can be endogenous (or “self”), originating from …

In this review, we aim to explore the multifaceted roles of galectins in host defense from a
broader perspective, particularly regarding their functions when host integrity is …

Hematopoiesis-the formation of blood cell components-continually replenishes the blood
system during embryonic development and postnatal lifespans. This coordinated process …

ABO blood group antigens, which are complex carbohydrate moieties, and the first human
polymorphisms identified, are critical in transfusion medicine and transplantation. Despite …

Abstract Background Galectins (Gal's) are a family of carbohydrate-binding proteins that are
known to support the tumour microenvironment through their immunosuppressive activity …

The dimeric architecture of tandem-repeat type galectins, such as galectin-4 (Gal-4),
modulates their biological activities, although the underlying molecular mechanisms have …

Glycans linked to proteins and lipids and also occurring in free forms have many functions,
and these are partly elicited through specific interactions with glycan-binding proteins …