[HTML][HTML] Multinucleated giant cells: current insights in phenotype, biological activities, and mechanism of formation

K Ahmadzadeh, M Vanoppen, CD Rose… - Frontiers in Cell and …, 2022 - frontiersin.org
Monocytes and macrophages are innate immune cells with diverse functions ranging from
phagocytosis of microorganisms to forming a bridge with the adaptive immune system. A …

Immunomodulation for maxillofacial reconstructive surgery

SG Kim - Maxillofacial Plastic and Reconstructive Surgery, 2020 - Springer
Immunomodulation is a technique for the modulation of immune responses against graft
material to improve surgical success rates. The main target cell for the immunomodulation is …

Exploring the biomaterial-induced secretome: Physical bone substitute characteristics influence the cytokine expression of macrophages

M Barbeck, ML Schröder, S Alkildani, O Jung… - International Journal of …, 2021 - mdpi.com
In addition to their chemical composition various physical properties of synthetic bone
substitute materials have been shown to influence their regenerative potential and to …

[PDF][PDF] Fasciolosis: grading the histopathological lesions in naturally infected bovine liver in Mosul city

SS Al-Mahmood, HB Al-Sabaawy - Iraqi Journal of Veterinary Sciences, 2019 - iasj.net
Fasciolosis cause economic losses in cattle that breed in Iraq and the world. About 4% of
bovine liver's samples included in the current study exhibited classical pathological lesions …

Mycobacterium avium Infection of Multinucleated Giant Cells Reveals Association of Bacterial Survival to Autophagy and Cholesterol Utilization

JJ Joseph, A Leestemaker-Palmer… - Cellular …, 2023 - Wiley Online Library
Mycobacterium avium subsp. hominissuis (M. avium) is an opportunistic environmental
pathogen that typically infects patients with existing lung conditions such as cystic fibrosis or …

A Myeloid-Specific Lack of IL-4Rα Prevents the Development of Alternatively Activated Macrophages and Enhances Immunity to Experimental Cysticercosis

JE Olguín, E Corano-Arredondo, V Hernández-Gómez… - Pathogens, 2024 - mdpi.com
To determine the role that the IL-4/IL13 receptor plays in the development of alternatively
activated macrophages (AAM or M2) and their role in the regulation of immunity to the …

Gm-csf and il-33 orchestrate polynucleation and polyploidy of resident murine alveolar macrophages in a murine model of allergic asthma

KM Quell, K Dutta, ÜR Korkmaz… - International Journal of …, 2020 - mdpi.com
Allergic asthma is a chronical pulmonary disease with high prevalence. It manifests as a
maladaptive immune response to common airborne allergens and is characterized by …

TRIM34 facilitates the formation of multinucleated giant cells by enhancing cell fusion and phagocytosis in epithelial cells

D Sun, X An, B Ji - Experimental Cell Research, 2019 - Elsevier
Persistent microbial infection promotes the fusion of several kinds of somatic cells, such as
macrophages and endothelial cells, leading to the formation of multinucleated giant cells …

Mechanism and Microtubule Requirements of Macrophage-derived Giant Cell Formation

FS Naimi - 2022 - search.proquest.com
Macrophages are effector cells of the innate immune system that are important for the
phagocytosis of foreign organisms. Under certain circumstances, macrophages can fuse into …

Characterization of Mycobacterium avium subsp. hominissuis Interactions with Host Macrophages and Multinucleated Giant Cells

JJ Joseph - 2022 - ir.library.oregonstate.edu
To examine the macrophage response to M. avium, I compared inflammasome and cytosolic
sensor expression and activation. My result demonstrated that virulent strains of M. avium …