The epithelial barrier is a critical border that segregates luminal material from entering
tissues. Essential components of this epithelial fence are physical intercellular structures …

Hepatitis C virus (HCV) infection is a global health problem that impacts approximately 180
million individuals. Of those initially infected with HCV approximately 80% will progress to …

RNA viruses have evolved elaborate strategies to protect their genomes, including 5′
capping. However, until now no RNA 5′ cap has been identified for hepatitis C virus,(HCV) …

ABSTRACT A tight junction (TJ) protein, claudin-1 (CLDN1), was identified recently as a key
factor for hepatitis C virus (HCV) entry. Here, we show that another TJ protein, occludin, is …

The tetraspanin transmembrane proteins have emerged as key players in malignancy, the
immune system, during fertilization and infectious disease processes. Tetraspanins engage …

Viruses initiate infection by attaching to molecules or receptors at the cell surface. Hepatitis
C virus (HCV) enters cells via a multistep process involving tetraspanin CD81, scavenger …

Hepatitis C virus (HCV) is a hepatotropic virus and a major cause of chronic hepatitis and
liver disease worldwide. Initial interactions between HCV virions and hepatocytes are …

Hepatitis C virus (HCV) is a major cause of liver cirrhosis and hepatocellular carcinoma.
Preventive modalities are absent and the current antiviral treatment is limited by resistance …

Hepatitis C virus (HCV), a major cause of chronic liver disease, is a single-stranded positive
sense virus of the family Flaviviridae. HCV cell entry is a multi-step process, involving …

Hepatitis C virus (HCV) leads to progressive liver disease and hepatocellular carcinoma.
Current treatments are only partially effective, and new therapies targeting viral and host …