Store-operated calcium channels (SOCs) are a major pathway for calcium signaling in
virtually all metozoan cells and serve a wide variety of functions ranging from gene …

Plasma-membrane-localized Orai1 ion channel subunits interacting with ER-localized
STIM1 molecules comprise the major subunit composition responsible for calcium release …

The store-operated Ca2+ release-activated Ca2+ (CRAC) channel is activated by
diminished luminal Ca2+ levels in the endoplasmic reticulum and sarcoplasmic reticulum …

Cellular homeostasis relies upon precise regulation of Ca2+ concentration. Stromal
interaction molecule (STIM) proteins regulate store-operated calcium entry (SOCE) by …

Key points Pharmacological and molecular inhibition of transient receptor potential
melastatin 7 (TRPM7) reduces store‐operated calcium entry (SOCE). Overexpression of …

Oral cancer causes pain associated with cancer progression. We report here that the
function of the Ca2+ channel ORAI1 is an important regulator of oral cancer pain. ORAI1 …

Abstract Store-operated Ca 2+ entry (SOCE) is a Ca 2+ entry mechanism activated by
depletion of intracellular Ca 2+ stores. In skeletal muscle, SOCE is mediated by an …

Store‐operated Ca2+ entry through Orai1 channels is a primary mechanism for Ca2+ entry
in many cells and mediates numerous cellular effector functions ranging from gene …

The family of stromal interaction molecules (STIM) includes two widely expressed single‐
pass endoplasmic reticulum (ER) transmembrane proteins and additional splice variants …

Sigma1 receptors (σ1Rs) are expressed widely; they bind diverse ligands, including
psychotropic drugs and steroids, regulate many ion channels, and are implicated in cancer …