The clinical course and outcome of COVID-19 are highly variable, ranging from
asymptomatic infections to severe disease and death. Understanding the risk factors of …

Background To summarize modifiable factors for coronavirus disease 2019 (COVID-19)
suggested by Mendelian randomization studies. Methods In this systematic review, we …

Several traditional observational studies suggested an association between COVID‐19 and
leukocyte telomere length (LTL), a biomarker for biological age. However, whether there …

The role of telomeres in human health and disease is yet to be fully understood. The
limitations of mouse models for the study of human telomere biology and difficulties in …

Socio-economic status (SES) and biological aging are risk factors for dementia, including
Alzheimer's disease, however, it is less clear if the associations with SES vary sufficiently …

CD8+ T lymphocytes are a heterogeneous class of cells that play a crucial role in the
adaptive immune response against pathogens and cancer. During their lifetime, they …

Telomerase levels in most human cells are insufficient to prevent loss of telomeric DNA with
each replication cycle. The resulting “Hayflick” limit may have allowed lifespan to increase …

Summary Background Severe COVID-19 T-cell lymphopenia is more common among older
adults and entails poor prognosis. Offsetting the decline in T-cell count during COVID-19 …

The COVID-19 pandemic caused by SARS-CoV-2 infection has been of unprecedented
clinical and socio-economic worldwide relevance. The case fatality rate for COVID-19 grows …

Genome-wide association studies (GWASs) have successfully identified thousands of
genetic variants that are reliably associated with human traits. Although GWASs are …