Brain insulin resistance in Alzheimer's disease and related disorders: mechanisms and therapeutic approaches

D Kellar, S Craft - The Lancet Neurology, 2020 - thelancet.com
Insulin is a peptide secreted by the pancreas and plays an important role in the regulation of
glucose metabolism in peripheral tissues. Although the role of insulin in the periphery is well …

Microglia and monocytes in inflammatory CNS disease: integrating phenotype and function

AG Spiteri, CL Wishart, R Pamphlett, G Locatelli… - Acta …, 2022 - Springer
In neurological diseases, the actions of microglia, the resident myeloid cells of the CNS
parenchyma, may diverge from, or intersect with, those of recruited monocytes to drive …

The neuropathological diagnosis of Alzheimer's disease

MA DeTure, DW Dickson - Molecular neurodegeneration, 2019 - Springer
Alzheimer's disease is a progressive neurodegenerative disease most often associated with
memory deficits and cognitive decline, although less common clinical presentations are …

Defective mitophagy and synaptic degeneration in Alzheimer's disease: Focus on aging, mitochondria and synapse

H Morton, S Kshirsagar, E Orlov, LE Bunquin… - Free Radical Biology …, 2021 - Elsevier
Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by
memory loss and multiple cognitive impairments. AD is marked by multiple cellular changes …

RhoA signaling in neurodegenerative diseases

SI Schmidt, M Blaabjerg, K Freude, M Meyer - Cells, 2022 - mdpi.com
Ras homolog gene family member A (RhoA) is a small GTPase of the Rho family involved in
regulating multiple signal transduction pathways that influence a diverse range of cellular …

Synaptic basis of Alzheimer's disease: Focus on synaptic amyloid beta, P-tau and mitochondria

A John, PH Reddy - Ageing research reviews, 2021 - Elsevier
Alzheimer's disease (AD) is a progressive and synaptic failure disease. Despite the many
years of research, AD still harbors many secrets. As more of the world's population grows …

Microglial Piezo1 senses Aβ fibril stiffness to restrict Alzheimer's disease

J Hu, Q Chen, H Zhu, L Hou, W Liu, Q Yang, H Shen… - Neuron, 2023 - cell.com
The pathology of Alzheimer's disease (AD) is featured with extracellular amyloid-β (Aβ)
plaques, whose impact on the mechanical properties of the surrounding brain tissues is …

Targeted complement inhibition at synapses prevents microglial synaptic engulfment and synapse loss in demyelinating disease

S Werneburg, J Jung, RB Kunjamma, SK Ha… - Immunity, 2020 - cell.com
Multiple sclerosis (MS) is a demyelinating, autoimmune disease of the central nervous
system. While work has focused on myelin and axon loss in MS, less is known about …

Dendritic tau in Alzheimer's disease

A Ittner, LM Ittner - Neuron, 2018 - cell.com
The microtubule-associated protein tau and amyloid-β (Aβ) are key players in Alzheimer's
disease (AD). Aβ and tau are linked in a molecular pathway at the post-synapse with tau …

Deregulated mitochondrial microRNAs in Alzheimer's disease: focus on synapse and mitochondria

P Gowda, PH Reddy, S Kumar - Ageing research reviews, 2022 - Elsevier
Alzheimer's disease (AD) is the most common cause of dementia and is currently one of the
biggest public health concerns in the world. Mitochondrial dysfunction in neurons is one of …