As knowledge of cell metabolism has advanced, glutamine has been considered an
important amino acid that supplies carbon and nitrogen to fuel biosynthesis. A recent study …

Solute carrier (SLC) transporters meditate many essential physiological functions, including
nutrient uptake, ion influx/efflux, and waste disposal. In its protective role against tumors and …

Glutamine is an essential nutrient that regulates energy production, redox homeostasis, and
signaling in cancer cells. Despite the importance of glutamine in mitochondrial metabolism …

Tumorigenesis is associated with elevated glucose and glutamine consumption, but how
cancer cells can sense their levels to activate lipid synthesis is unknown. Here, we reveal …

Clustered regularly interspaced palindromic repeats (CRISPR) is a gene editing tool with
tremendous therapeutic potential. Recently, ribonucleoprotein (RNP) complex‐based …

Amino acids are indispensable for the growth of cancer cells. This includes essential amino
acids, the carbon skeleton of which cannot be synthesized, and conditionally essential …

Glioma is the most common type of primary malignant tumor in the central nervous system
with limited treatment satisfaction. Finding new therapeutic targets has remained a major …

Abstract The human Alanine Serine Cysteine Transporter 2 (ASCT2) is a neutral amino acid
exchanger that belongs to the solute carrier family 1 (SLC1A). SLC1A structures have …

Background Glutamine is an abundant and versatile nutrient in cancer cells. Head and neck
squamous cell carcinoma (HNSCC) was reported to be dependent on mainly glucose, not …

Transmembrane transport of small organic and inorganic molecules is one of the
cornerstones of cellular metabolism. Among transmembrane transporters, solute carrier …