Potassium channels in Parkinson's disease: potential roles in its pathogenesis and innovative molecular targets for treatment

X Chen, Y Feng, RJ Quinn, DL Pountney… - Pharmacological …, 2023 - Elsevier
Parkinson's disease (PD) is a neurodegenerative disorder characterized by selective loss of
dopaminergic neurons in the substantia nigra pars compacta (SNpc) region of the midbrain …

Microglial phenotypic transition: signaling pathways and influencing modulators involved in regulation in central nervous system diseases

J Li, X Shui, R Sun, L Wan, B Zhang, B Xiao… - Frontiers in Cellular …, 2021 - frontiersin.org
Microglia are macrophages that reside in the central nervous system (CNS) and belong to
the innate immune system. Moreover, they are crucially involved in CNS development …

[HTML][HTML] The complex role of inflammation and gliotransmitters in Parkinson's disease

A Gopinath, PM Mackie, LT Phan, MG Tansey… - Neurobiology of …, 2023 - Elsevier
Our understanding of the role of innate and adaptive immune cell function in brain health
and how it goes awry during aging and neurodegenerative diseases is still in its infancy …

Ion channels and transporters in microglial function in physiology and brain diseases

L Luo, S Song, CC Ezenwukwa, S Jalali, B Sun… - Neurochemistry …, 2021 - Elsevier
Microglial cells interact with all components of the central nervous system (CNS) and are
increasingly recognized to play essential roles during brain development, homeostasis and …

Coumarins derivatives and inflammation: Review of their effects on the inflammatory signaling pathways

B Rostom, R Karaky, I Kassab, MSI Veitía - European Journal of …, 2022 - Elsevier
Natural and synthetic coumarins have been extensively described in the literature as
effective drugs with several pharmacological activities. Many valuable publications have …

Microglia as therapeutic target for radiation-induced brain injury

Q Liu, Y Huang, M Duan, Q Yang, B Ren… - International journal of …, 2022 - mdpi.com
Radiation-induced brain injury (RIBI) after radiotherapy has become an increasingly
important factor affecting the prognosis of patients with head and neck tumor. With the …

The potential convergence of NLRP3 inflammasome, potassium, and dopamine mechanisms in Parkinson's disease

AF Pike, I Szabò, R Veerhuis, L Bubacco - npj Parkinson's Disease, 2022 - nature.com
The pathology of Parkinson's disease (PD) is characterized by α-synuclein aggregation,
microglia-mediated neuroinflammation, and dopaminergic neurodegeneration in the …

Peroxisom proliferator-activated receptor-γ coactivator-1α in neurodegenerative disorders: A promising therapeutic target

YN Yang, MQ Zhang, FL Yu, B Han, MY Bao… - Biochemical …, 2023 - Elsevier
Neurodegenerative disorders (NDDs) are characterized by progressive loss of selectively
vulnerable neuronal populations and myelin sheath, leading to behavioral and cognitive …

Src family kinases (SFKs): critical regulators of microglial homeostatic functions and neurodegeneration in Parkinson's and Alzheimer's diseases

CC Portugal, TO Almeida, R Socodato… - The FEBS …, 2022 - Wiley Online Library
c‐Src was the first protein kinase to be described as capable of phosphorylating tyrosine
residues. Subsequent identification of other tyrosine‐phosphorylating protein kinases with a …

Aptamer functionalized cell membrane for brain and nerve cell sensing with high sensitivity and stability

H Wu, Z Meng, J Wang, G Yao, L Yang, Z Zeng… - Biosensors and …, 2023 - Elsevier
Accurate dopamine (DA) monitoring with high stability is essential for investigating the
chemical basis of brain function and pathology. Electrochemical-based tissue-implantable …