Diet-derived fatty acids (FAs) are essential sources of energy and fundamental structural
components of cells. They also play important roles in the modulation of immune responses …

Endothelial dysfunction contributes to cardiovascular diseases, including hypertension,
atherosclerosis, and coronary artery disease, which are also characterized by insulin …

Insulin has important vascular actions to stimulate production of nitric oxide from
endothelium. This leads to capillary recruitment, vasodilation, increased blood flow, and …

Objective In the present review, we try to critically evaluate the two faces of the macrophages
and their roles in relation to gene alteration in some inflammatory conditions. The pros-and …

This review highlights the inflammatory and insulin-antagonizing effects of saturated fatty
acids (SFA), which contribute to the development of metabolic syndrome. Mechanisms …

Skeletal muscles contain resident immune cell populations and their abundance and type is
altered in inflammatory myopathies, endotoxemia or different types of muscle injury/insult …

Here we report that in skeletal muscle cells the contribution to insulin resistance and
inflammation of two common dietary long-chain fatty acids depends on the channeling of …

There is increasing evidence showing that chronic inflammation is an important pathogenic
mediator of the development of type 2 diabetes (T2D). It is now generally accepted that …

Mounting evidence indicates that elevated intramyocellular triacylglycerol concentrations
are associated with diminished insulin sensitivity in skeletal muscle. This lipid accumulation …

Hypertension commonly occurs in conjunction with insulin resistance and other components
of the cardiometabolic syndrome. Insulin resistance plays a significant role in the …