High mobility group box 1 (HMGB1) is a nonhistone nuclear protein that has multiple
functions according to its subcellular location. In the nucleus, HMGB1 is a DNA chaperone …

The lung is a primary organ for gas exchange in mammals that represents the largest
epithelial surface in direct contact with the external environment. It also serves as a crucial …

Danger signals are a hallmark of many common inflammatory diseases, and these stimuli
can function to activate the cytosolic innate immune signalling receptor NLRP3 (NOD-, LRR …

Inflammasomes are large cytosolic multiprotein complexes assembled in response to
infection and cellular stress, and are crucial for the activation of inflammatory caspases and …

Klebsiella species cause a wide range of diseases including pneumonia, urinary tract
infections (UTIs), bloodstream infections and sepsis. These infections are particularly a …

Inflammation is an important driver of atherosclerosis, the underlying pathology of
cardiovascular diseases. Therefore, therapeutic targeting of inflammatory pathways is …

Mountainous evidence suggests that inflammation, cardiomyocyte apoptosis and pyroptosis
are involved in the development of sepsis and sepsis-induced cardiomyopathy (SIC) …

Like the organism they constitute, the cells also die in different ways. The death can be
predetermined, programmed, and cleanly executed, as in the case of apoptosis, or it can be …

Klebsiella pneumoniae causes a wide range of infections, including pneumonias, urinary
tract infections, bacteremias, and liver abscesses. Historically, K. pneumoniae has caused …

Inflammasomes are newly recognized, vital players in innate immunity. The best
characterized is the NLRP3 inflammasome, so-called because the NLRP3 protein in the …