Ubiquitination is a critical type of post-translational modifications, of which K63-linked
ubiquitination regulates interaction, translocation, and activation of proteins. In recent years …

Since TGF-β was recognized as an essential secreted cytokine in embryogenesis and adult
tissue homeostasis a decade ago, our knowledge of the role of TGF-β in mammalian …

Gastric cancer (GC) is the most common malignant tumor of digestive system. Bufalin
extracted from Venenum Bufonis is one of the most effective anticancer monomers, which …

CD4+ T cells play a notable role in immune protection at different stages of life. During
aging, the interaction between the body's internal and external environment and CD4+ T …

Transforming growth factor β (TGF-β), a versatile immunosuppressive cytokine, has gained
increasing attention as a potential target for cancer immunotherapy. However, current …

Although immune checkpoint-based cancer immunotherapy has shown significant efficacy
in various cancers, resistance still limits its therapeutic effects. Ubiquitination modification is …

PD-1 blockade rescues failing anticancer immune responses, resulting in durable
remissions in some cancer patients. Cytokines such as IFNγ and IL-2 contribute to the anti …

Aging compromises antitumor immunity, but the underlying mechanisms remain elusive.
Here, we report that aging impairs the generation of CD8+ tissue resident memory T (TRM) …

Insufficient infiltration of T cells severely compromises the antitumor efficacy of adoptive cell
therapy (ACT) against solid tumors. Here, we present a facile immune cell surface …

Glioblastoma (GBM) is a highly malignant brain cancer with a poor prognosis despite
standard treatments. This investigation aimed to explore the feasibility of PTPN6 to combat …