Fast synaptic communication in the brain requires synchronous vesicle fusion that is evoked
by action potential-induced Ca2+ influx. However, synaptic terminals also release …

Neurotransmission is sustained by endocytosis and refilling of synaptic vesicles (SVs)
locally within the presynapse. Until recently, a consensus formed that after exocytosis, SVs …

Botulinum neurotoxins are known to have seven serotypes (BoNT/A–G). Here we report a
new BoNT serotype, tentatively named BoNT/X, which has the lowest sequence identity with …

Most neuronal communication relies upon the synchronous release of neurotransmitters,
which occurs through synaptic vesicle exocytosis triggered by action potential invasion of a …

Neuronal communication crucially relies on exocytosis of neurotransmitters from synaptic
vesicles (SVs) which are clustered at synapses. To ensure reliable neurotransmitter release …

Synaptic vesicle recycling is one of the best‐studied cellular pathways. Many of the proteins
involved are known, and their interactions are becoming increasingly clear. However, as for …

A single, low dose of ketamine evokes antidepressant actions in depressed patients and in
patients with treatment-resistant depression (TRD). Unlike classic antidepressants, which …

The function of the nervous system depends on the exocytotic release of neurotransmitter
from synaptic vesicles (SVs). To sustain neurotransmission, SV membranes need to be …

Recent clinical studies have demonstrated that a single subpsychotomimetic dose of
ketamine, an ionotropic glutamatergic N-methyl-d-aspartate (NMDA) receptor antagonist …

Synaptic vesicles fuse with the plasma membrane to release neurotransmitter following an
action potential, after which new vesicles must 'dock'to refill vacated release sites. To …