Clinical research challenges posed by difficult-to-treat depression
AJ Rush, HA Sackeim, CR Conway… - Psychological …, 2022 - cambridge.org
Approximately one-third of individuals in a major depressive episode will not achieve
sustained remission despite multiple, well-delivered treatments. These patients experience …
sustained remission despite multiple, well-delivered treatments. These patients experience …
Single-dose psilocybin treatment for major depressive disorder: a randomized clinical trial
CL Raison, G Sanacora, J Woolley, K Heinzerling… - Jama, 2023 - jamanetwork.com
Importance Psilocybin shows promise as a treatment for major depressive disorder (MDD).
Objective To evaluate the magnitude, timing, and durability of antidepressant effects and …
Objective To evaluate the magnitude, timing, and durability of antidepressant effects and …
[HTML][HTML] Efficacy and safety of transcranial magnetic stimulation for treating major depressive disorder: An umbrella review and re-analysis of published meta-analyses …
S Brini, NI Brudasca, A Hodkinson, K Kaluzinska… - Clinical psychology …, 2023 - Elsevier
Objectives We re-analysed data from published meta-analyses testing the effects of
Transcranial Magnetic Stimulation (TMS) on Major Depressive Disorder (MDD) in adults. We …
Transcranial Magnetic Stimulation (TMS) on Major Depressive Disorder (MDD) in adults. We …
Treatment‐resistant depression: definition, prevalence, detection, management, and investigational interventions
Treatment‐resistant depression (TRD) is common and associated with multiple serious
public health implications. A consensus definition of TRD with demonstrated predictive utility …
public health implications. A consensus definition of TRD with demonstrated predictive utility …
Connectivity-guided intermittent theta burst versus repetitive transcranial magnetic stimulation for treatment-resistant depression: a randomized controlled trial
Disruption in reciprocal connectivity between the right anterior insula and the left
dorsolateral prefrontal cortex is associated with depression and may be a target for …
dorsolateral prefrontal cortex is associated with depression and may be a target for …
Real world transcranial magnetic stimulation for major depression: A multisite, naturalistic, retrospective study
Abstract Background In 2008, the US FDA approved rTMS as a treatment against medication-
resistant depression. However, real-world rTMS outcomes remain understudied. This study …
resistant depression. However, real-world rTMS outcomes remain understudied. This study …
Clinically significant changes in the 17-and 6-Item Hamilton Rating Scales for Depression: a STAR* D report
Objective To develop clinically meaningful improvement thresholds in both the 17-item and
the 6-item Hamilton Rating Scale for Depression (HRSD) total scores in depressed …
the 6-item Hamilton Rating Scale for Depression (HRSD) total scores in depressed …
Psilocybin therapy for clinicians with symptoms of depression from frontline care during the COVID-19 pandemic: a randomized clinical trial
AL Back, TK Freeman-Young, L Morgan… - JAMA Network …, 2024 - jamanetwork.com
Importance The psychological morbidity experienced by physicians, advanced practice
practitioners (APPs), and nurses from working during the COVID-19 pandemic includes …
practitioners (APPs), and nurses from working during the COVID-19 pandemic includes …
[HTML][HTML] IN Esketamine and IV ketamine: results of a multi-site observational study assessing the effectiveness and tolerability of two novel therapies for treatment …
Intravenous (IV) ketamine and intranasal (IN) esketamine are novel therapies to manage
treatment resistant depression within major depressive disorder (MDD-TRD). This is a multi …
treatment resistant depression within major depressive disorder (MDD-TRD). This is a multi …
A pilot randomized controlled trial of online written exposure therapy delivered by peer coaches to veterans with posttraumatic stress disorder
This pilot randomized clinical trial (RCT) sought to examine the preliminary efficacy of an
internet‐based version of written exposure therapy delivered to veterans through an online …
internet‐based version of written exposure therapy delivered to veterans through an online …