High throughput toxicity screening and intracellular detection of nanomaterials

AR Collins, B Annangi, L Rubio… - Wiley …, 2017 - Wiley Online Library
With the growing numbers of nanomaterials (NMs), there is a great demand for rapid and
reliable ways of testing NM safety—preferably using in vitro approaches, to avoid the ethical …

[HTML][HTML] Real-time cell analysis system in cytotoxicity applications: Usefulness and comparison with tetrazolium salt assays

J Stefanowicz-Hajduk, JR Ochocka - Toxicology reports, 2020 - Elsevier
Real-time cell analysis (RTCA) is a technique based on impedance and microsensor
electrodes. RTCA system allows label-free, real-time, and continuous monitoring of cell …

Application of xCELLigence RTCA biosensor technology for revealing the profile and window of drug responsiveness in real time

D Kho, C MacDonald, R Johnson, CP Unsworth… - Biosensors, 2015 - mdpi.com
The xCELLigence technology is a real-time cellular biosensor, which measures the net
adhesion of cells to high-density gold electrode arrays printed on custom-designed E-plates …

Alpha-Hederin, the Active Saponin of Nigella sativa, as an Anticancer Agent Inducing Apoptosis in the SKOV-3 Cell Line

A Adamska, J Stefanowicz-Hajduk, JR Ochocka - Molecules, 2019 - mdpi.com
Alpha-hederin (α-HN), a pentacyclic triterpene saponin, has recently been identified as one
of the active compounds of Nigella sativa, as a potential anticancer agent. However, no …

Sex-specific stress response and HMGB1 release in pulmonary endothelial cells

M Zemskova, S Kurdyukov, J James, N McClain… - PLoS …, 2020 - journals.plos.org
Women are known to be associated with a higher susceptibility to pulmonary arterial
hypertension (PAH). In contrast, male PAH patients have a worse survival prognosis. In this …

[HTML][HTML] Local administration of shikonin improved the overall survival in orthotopic murine glioblastoma models with temozolomide resistance

R Maeoka, Y Ouji, T Nakazawa, R Matsuda… - Biomedicine & …, 2023 - Elsevier
Background Glioblastoma is a type of intracranial malignancy. Shikonin, a Chinese
traditional medicine, has been shown to have anti-tumor efficacy toward human …

[HTML][HTML] Screening and evaluation of antiviral compounds against Equid alpha-herpesviruses using an impedance-based cellular assay

CJ Thieulent, ES Hue, CI Fortier, P Dallemagne… - Virology, 2019 - Elsevier
Equid alpha-herpesviruses (EHV) are responsible for different diseases in equine
population. EHV-1 causes respiratory diseases, abortions and nervous disorders, EHV-4 …

Development of a high-content screen for the identification of inhibitors directed against the early steps of the cytomegalovirus infectious cycle

TJ Gardner, T Cohen, V Redmann, Z Lau, D Felsenfeld… - Antiviral research, 2015 - Elsevier
Human cytomegalovirus (CMV) is a latent and persistent virus whose proliferation increases
morbidity and mortality of immune-compromised individuals. The current anti-CMV …

State-of-the-art methods and devices for the generation, exposure, and collection of aerosols from heat-not-burn tobacco products

S Boué, D Goedertier, J Hoeng… - Toxicology …, 2020 - journals.sagepub.com
Tobacco harm reduction is increasingly recognized as a promising approach to accelerate
the decline in smoking prevalence and smoking-related population harm. Potential modified …

Artesunate Demonstrates in vitro Synergism with Several Antiviral Agents against Human Cytomegalovirus

E Drouot, J Piret, G Boivin - 2016 - journals.sagepub.com
Background Human cytomegalovirus (HCMV) infections remain a major problem in
immunocompromised patients. Three antiviral agents, ganciclovir (GCV), foscarnet (FOS) …