The epidemiology, pathogenesis, transmission, diagnosis, and management of multidrug-resistant, extensively drug-resistant, and incurable tuberculosis

K Dheda, T Gumbo, G Maartens, KE Dooley… - The lancet Respiratory …, 2017 - thelancet.com
Global tuberculosis incidence has declined marginally over the past decade, and
tuberculosis remains out of control in several parts of the world including Africa and Asia …

Therapeutic drug monitoring in the treatment of tuberculosis: an update

A Alsultan, CA Peloquin - Drugs, 2014 - Springer
Tuberculosis (TB) is the world's second leading infectious killer. Cases of multidrug-resistant
(MDR-TB) and extremely drug-resistant (XDR-TB) have increased globally. Therapeutic …

Treatment of tuberculosis. A historical perspective

JF Murray, DE Schraufnagel… - Annals of the American …, 2015 - atsjournals.org
Of all achievements in medicine, the successful treatment of tuberculosis has had one of the
greatest impacts on society. Tuberculosis was a leading cause of disease and a mortal …

An updated systematic review and meta-analysis for treatment of multidrug-resistant tuberculosis

ML Bastos, Z Lan, D Menzies - European Respiratory Journal, 2017 - Eur Respiratory Soc
This systematic review aimed to update the current evidence for multidrug-resistant
tuberculosis (MDR-TB) treatment. We searched for studies that reported treatment …

[HTML][HTML] MDR tuberculosis treatment

J Espinosa-Pereiro, A Sánchez-Montalvá, ML Aznar… - Medicina, 2022 - mdpi.com
Multidrug-resistant (MDR) tuberculosis (TB), resistant to isoniazid and rifampicin, continues
to be one of the most important threats to controlling the TB epidemic. Over the last few …

[HTML][HTML] New tuberculosis drug leads from naturally occurring compounds

D Quan, G Nagalingam, R Payne, JA Triccas - International Journal of …, 2017 - Elsevier
Tuberculosis (TB) continues to be a significant cause of mortality and morbidity worldwide.
An estimated 2 billion individuals are infected with Mycobacterium tuberculosis and annually …

Perspectives on advances in tuberculosis diagnostics, drugs, and vaccines

M Schito, GB Migliori, HA Fletcher… - Clinical infectious …, 2015 - academic.oup.com
Despite concerted efforts over the past 2 decades at developing new diagnostics, drugs, and
vaccines with expanding pipelines, tuberculosis remains a global emergency. Several novel …

Mycobacteriophage D29 Lysin B exhibits promising anti-mycobacterial activity against drug-resistant Mycobacterium tuberculosis

AK Singh, R Gangakhedkar, HS Thakur… - Microbiology …, 2023 - Am Soc Microbiol
The emergence of antibiotic resistance in Mycobacterium tuberculosis has been the culprit
behind the inefficient treatment of tuberculosis (TB). Mycobacteriophages being rapid and …

Fluoroquinolone efficacy against tuberculosis is driven by penetration into lesions and activity against resident bacterial populations

J Sarathy, L Blanc, N Alvarez-Cabrera… - Antimicrobial agents …, 2019 - Am Soc Microbiol
Fluoroquinolones represent the pillar of multidrug-resistant tuberculosis (MDR-TB)
treatment, with moxifloxacin, levofloxacin, or gatifloxacin being prescribed to MDR-TB …

[HTML][HTML] Comparing efficacies of moxifloxacin, levofloxacin and gatifloxacin in tuberculosis granulomas using a multi-scale systems pharmacology approach

E Pienaar, J Sarathy, B Prideaux… - PLoS computational …, 2017 - journals.plos.org
Granulomas are complex lung lesions that are the hallmark of tuberculosis (TB).
Understanding antibiotic dynamics within lung granulomas will be vital to improving and …