Meta-analyses of genome-wide association studies (meta-GWASs) and candidate gene
studies have identified genetic variants associated with cardiovascular diseases, metabolic …

Adequate oxygen supply is essential for the human brain to meet its high energy demands.
Therefore, elaborate molecular and systemic mechanism are in place to enable adaptation …

Probiotics have been reported to exert beneficial effects along the gut-brain axis. This
randomised, double-blind and placebo-controlled human study aimed to evaluate such …

Complex multicellular organisms require a coordinated response from multiple tissues to
maintain whole-body homeostasis in the face of energetic stressors such as fasting, cold …

Psychological stresses are associated with cardiovascular diseases to the extent that
cardiovascular diseases are among the most important group of psychosomatic diseases …

Oxidative and inflammatory signaling pathways have been identified as important targets for
mitigating hypoxic stress-induced neurological complications. Thus, the effects of …

The gut microbiota has been increasingly correlated with depressive disorder. It was
recently shown that the transplantation of the gut microbiota from depressed patients to …

Now astrocytes appear to be the key contributors to the pathophysiology of major
depression. Evidence in rodents shows that chronic stress is associated with a decreased …

Chronic stress has a detrimental effect on neurological insults, psychiatric deficits, and
cognitive impairment. In the current study, chronic stress was shown to impair learning and …

Background Sinomenine (SIN) is an extract of the Chinese medicinal herb Sinomenium
acutum; it has various pharmacological properties, including immunosuppression and anti …