PET imaging of proliferation with pyrimidines
OS Tehrani, AF Shields - Journal of Nuclear Medicine, 2013 - Soc Nuclear Med
Several new tracers are being developed for use with PET to assess pathways that are
altered in cancers, including energy use, cellular signaling, transport, and proliferation …
altered in cancers, including energy use, cellular signaling, transport, and proliferation …
Clinical value of 3'-deoxy-3'-[18F]fluorothymidine-positron emission tomography for diagnosis, staging and assessing therapy response in lung cancer
Lung cancer has the highest mortality rate of any tumour type. The main driver of lung
tumour growth and development is uncontrolled cellular proliferation. Poor patient outcomes …
tumour growth and development is uncontrolled cellular proliferation. Poor patient outcomes …
Inhibition of carbonic anhydrases IX/XII by SLC-0111 boosts cisplatin effects in hampering head and neck squamous carcinoma cell growth and invasion
A Sarnella, Y Ferrara, L Auletta, S Albanese… - Journal of Experimental …, 2022 - Springer
Background Hypoxic tumor microenvironment (TME) contributes to the onset of many
aspects of the cancer biology associated to the resistance to conventional therapies …
aspects of the cancer biology associated to the resistance to conventional therapies …
Reversal of warburg effect and reactivation of oxidative phosphorylation by differential inhibition of EGFR signaling pathways in non–small cell lung cancer
Purpose: One of the hallmarks of cancer cells is the excessive conversion of glucose to
lactate under normoxic conditions, also known as the Warburg effect. Here, we tested …
lactate under normoxic conditions, also known as the Warburg effect. Here, we tested …
[HTML][HTML] Inhibition of bone marrow-derived mesenchymal stem cells homing towards triple-negative breast cancer microenvironment using an anti-PDGFRβ aptamer
S Camorani, BS Hill, R Fontanella, A Greco… - Theranostics, 2017 - ncbi.nlm.nih.gov
Bone marrow-derived mesenchymal stem cells (BM-MSCs) are shown to participate in tumor
progression by establishing a favorable tumor microenvironment (TME) that promote …
progression by establishing a favorable tumor microenvironment (TME) that promote …
[HTML][HTML] Targeted imaging and inhibition of triple-negative breast cancer metastases by a PDGFRβ aptamer
S Camorani, BS Hill, F Collina, S Gargiulo… - Theranostics, 2018 - ncbi.nlm.nih.gov
While the overall mortality for breast cancer has recently declined, management of triple-
negative breast cancer (TNBC) is still challenging because of its aggressive clinical …
negative breast cancer (TNBC) is still challenging because of its aggressive clinical …
Safety, efficacy, and pharmacokinetics of navitoclax (ABT-263) in combination with erlotinib in patients with advanced solid tumors
AW Tolcher, P LoRusso, J Arzt, TA Busman… - Cancer chemotherapy …, 2015 - Springer
Abstract Purpose Navitoclax (ABT-263), a novel, oral Bcl-2 inhibitor, enhances the antitumor
effects of chemotherapy in vitro by lowering the apoptotic threshold. This phase I study …
effects of chemotherapy in vitro by lowering the apoptotic threshold. This phase I study …
Therapeutic Potential of a Novel αvβ3 Antagonist to Hamper the Aggressiveness of Mesenchymal Triple Negative Breast Cancer Sub-Type
BS Hill, A Sarnella, D Capasso, D Comegna… - Cancers, 2019 - mdpi.com
The mesenchymal sub-type of triple negative breast cancer (MES-TNBC) has a highly
aggressive behavior and worse prognosis, due to its invasive and stem-like features, that …
aggressive behavior and worse prognosis, due to its invasive and stem-like features, that …
Autocrine signals increase ovine mesenchymal stem cells migration through Aquaporin‐1 and CXCR4 overexpression
A Pelagalli, A Nardelli, E Lucarelli… - Journal of Cellular …, 2018 - Wiley Online Library
Sheep is a relevant large animal model that is frequently used to test innovative tissue
engineering (TE) approaches especially for bone reconstruction. Mesenchymal stem cells …
engineering (TE) approaches especially for bone reconstruction. Mesenchymal stem cells …
Current applications for nuclear medicine imaging in pulmonary disease
JE Kusmirek, JD Magnusson, SB Perlman - Current Pulmonology Reports, 2020 - Springer
Abstract Purpose of Review The main goal of the article is to familiarize the reader with
commonly and uncommonly used nuclear medicine procedures that can significantly …
commonly and uncommonly used nuclear medicine procedures that can significantly …