We introduce density functional theory and review recent progress in its application to
transition metal chemistry. Topics covered include local, meta, hybrid, hybrid meta, and …

There have been significant advances in our understanding of mononuclear nonheme iron
oxygenases since our 1996 Chemical Reviews article, 1 promoted in large part by the many …

Structural regulation of the active centers is often pivotal in controlling the catalytic functions,
especially in iron-based oxidation systems. Here, we discovered a significantly altered …

The title to a seminar presentation by IC Gunsalus in 1973 was “Oxygen: An essential toxin”,
referring to the complex role that atmospheric dioxygen has in biology. The relatively simple …

Aerobic life on our planet relies on the use of molecular oxygen for energy as well as for
biosynthesis of important biological compounds in metabolic pathways. Thermodynamically …

Hepcidin is the master regulator of systemic iron homeostasis. Derived primarily from the
liver, it inhibits the iron exporter ferroportin in the gut and spleen, the sites of iron absorption …

Mononuclear non-heme ferrous iron dependent oxygenases and oxidases constitute an
extended enzyme family that catalyze a wide range of oxidation reactions. The largest …

General knowledge of dioxygen-activating mononuclear non-heme iron (II) enzymes
containing a 2-His-1-carboxylate facial triad has significantly expanded in the last few years …

The non-heme Fe enzymes are ubiquitous in nature and perform a wide range of functions
involving O2 activation. These had been difficult to study relative to heme enzymes; …

Oxidation of cyclobutanol by aqueous Fe (IV) generates cyclobutanone in∼ 70% yield. In
addition to this two-electron process, a smaller fraction of the reaction takes place by a one …