Viruses, as obligate intracellular parasites, are the pathogens that have the most intimate
relationship with their host, and as such, their genomes have been shaped directly by …

As obligate intracellular parasites, viruses are dependent on their infected hosts for survival.
Consequently, viruses are under enormous selective pressure to utilize available cellular …

Gene transcription is strictly controlled by transcriptional complexes, which are assemblies
of transcription factors, transcriptional regulators, and co-regulators. Mammalian genomes …

The human adenovirus type 5 (HAdV-5) E1A 13S oncoprotein is a potent regulator of gene
expression and is used extensively as a model for transcriptional activation. It possesses two …

Human adenovirus has evolved to infect and replicate in terminally differentiated human
epithelial cells, predominantly those within the airway, the gut, or the eye. To overcome the …

Deregulation of the cell cycle is of paramount importance during adenovirus infection.
Adenovirus normally infects quiescent cells and must initiate the cell cycle in order to …

The adenovirus E1A gene is the first gene expressed upon viral infection. E1A remodels the
cellular environment to maximize permissivity for viral replication. E1A is also the major …

Background Proteins of the C-terminal binding protein (CtBP) family, CtBP1 and CtBP2 are
closely related transcriptional regulators that are coded by two different gene loci in the …

The aberrant expression of the zinc finger protein 217 (ZNF217) promotes multiple
malignant phenotypes, such as replicative immortality, maintenance of proliferation …

Human adenovirus expresses several early proteins that control various aspects of the viral
replication program, including an orchestrated expression of viral genes. Two of the earliest …