Platelet-derived growth factor (PDGF) exerts its stimulatory effects on cell growth and motility
by binding to two related protein tyrosine kinase receptors. Ligand binding induces receptor …

Wortmannin is a fungal metabolite that so far has been shown to act as a selective inhibitor
of phosphoinositide 3-kinase. It can therefore be used to investigate the convergence …

The generation of phosphatidylinositide 3-phosphates has been observed in a variety of
cellular responses. The enzymes that mediate synthesis are the phosphoinositide 3-kinases …

Soleus muscles isolated from normal rats were incubated to evaluate whether or not leucine
promotes glucose uptake under insulin-free conditions, using a labeled 2-deoxyglucose …

Physical exercise induces translocation of GLUT4 from an intracellular pool to the cell
surface in skeletal muscles and increases glucose uptake via an insulin-independent …

We have isolated Swiss 3T3 subclones that are resistant to the mitogenic and morphological
transforming effects of v-Src as a consequence of aberrant translocation of the oncoprotein …

To elucidate the mechanisms of phosphatidylinositol (PI) 3-kinase involvement in insulin-
stimulated glucose transport activity, the epitope-tagged p110α subunit of PI 3-kinase was …

Recent experimental evidence has focused attention to the role of two molecules, insulin
receptor substrate 1 (IRS-1) and phosphatidylinositol 3-kinase (PI3-kinase), in linking the …

Metabolic diseases, such as diabetes, obesity, and fatty liver disease, have now reached
epidemic proportions. Receptor tyrosine kinases (RTKs) are a family of cell surface …

c-Myc-overexpressing mammary epithelial cells are proapoptotic; their survival is strongly
promoted by epidermal growth factor (EGF). We now demonstrate that EGF-induced Akt …