Sirtuin family members are characterized by either mono-ADP-ribosyltransferase or
deacylase activity and are linked to various cancer-related biological pathways as regulators …

Sirtuins are a highly conserved class of NAD+-dependent lysine deacylases. The human
isotype Sirt2 has been implicated in the pathogenesis of cancer, inflammation and …

Sirtuins use NAD+ to remove various acyl groups from protein lysine residues. Through
working on different substrate proteins, they display many biological functions, including …

New organometallic gold (III) and platinum (II) complexes containing iminophosphorane
ligands are described. Most of them are more cytotoxic to a number of human cancer cell …

Growing evidence suggests that changes in histone acetylation in specific sites of the
chromatin modulate neuronal plasticity and contribute to antidepressant-like action. Sirtuin 2 …

SIRT2 has been shown to possess NAD+-dependent deacetylase and desuccinylase
enzymatic activities, it also regulates metabolism homeostasis in mammals. Previous data …

The silent information regulator 2 related enzyme 2 (SIRT2) has been reported to have an
important role in tumorigenesis. Although two distinct effects of SIRT2 have recently been …

Rationale Antidepressant action has been linked to increased synaptic plasticity in which
epigenetic mechanisms such as histone posttranslational acetylation could be involved …

Introduction: The discovery and development of therapeutic strategies for the treatments of
Parkinson's disease (PD) and other synucleinopathies are limited by a lack of understanding …

The microtubule network exerts multifarious functions controlled by its decoration with
various proteins and post-translational modifications. The disordered microtubule …