Controlled human infection models to accelerate vaccine development

RKM Choy, AL Bourgeois… - Clinical Microbiology …, 2022 - Am Soc Microbiol
The timelines for developing vaccines against infectious diseases are lengthy, and often
vaccines that reach the stage of large phase 3 field trials fail to provide the desired level of …

Streptococcus pneumoniae colonization associates with impaired adaptive immune responses against SARS-CoV-2

E Mitsi, J Reiné, BC Urban, C Solórzano… - The Journal of …, 2022 - Am Soc Clin Investig
Background Although recent epidemiological data suggest that pneumococci may contribute
to the risk of SARS-CoV-2 disease, cases of coinfection with Streptococcus pneumoniae in …

Multiplex hybrid antigen-capture LC-MRM quantification in sera and nasal lining fluid of AZD7442, a SARS-CoV-2-targeting antibody combination

R Mu, Y Huang, J Bouquet, J Yuan, RJ Kubiak… - Analytical …, 2022 - ACS Publications
AZD7442 (tixagevimab [AZD8895]/cilgavimab [AZD1061]) is a monoclonal antibody (mAb)
combination in development for the prevention and treatment of coronavirus disease 2019 …

Association of Upper Respiratory Streptococcus pneumoniae Colonization With Severe Acute Respiratory Syndrome Coronavirus 2 Infection Among Adults

AM Parker, N Jackson, S Awasthi, H Kim… - Clinical Infectious …, 2023 - academic.oup.com
Background Streptococcus pneumoniae interacts with numerous viral respiratory pathogens
in the upper airway. It is unclear whether similar interactions occur with severe acute …

Association of upper respiratory Streptococcus pneumoniae colonization with SARS-CoV-2 infection among adults

AM Parker, N Jackson, S Awasthi, H Kim, T Alwan… - medRxiv, 2022 - medrxiv.org
Background Streptococcus pneumoniae interacts with numerous viral respiratory pathogens
in the upper airway. It is unclear whether similar interactions occur with SARS-CoV-2 …

[HTML][HTML] Inflammation of the nasal mucosa is associated with susceptibility to experimental pneumococcal challenge in older adults

BC Urban, ANA Gonçalves, D Loukov, FM Passos… - Mucosal …, 2024 - Elsevier
Streptococcus pneumoniae colonization in the upper respiratory tract is linked to
pneumococcal disease development, predominantly affecting young children and older …

Insights Into the Effects of Mucosal Epithelial and Innate Immune Dysfunction in Older People on Host Interactions With Streptococcus pneumoniae

CM Weight, SP Jochems, H Adler… - Frontiers in Cellular …, 2021 - frontiersin.org
In humans, nasopharyngeal carriage of Streptococcus pneumoniae is common and
although primarily asymptomatic, is a pre-requisite for pneumonia and invasive …

Assessing the use of minimally invasive self-sampling at home for long-term monitoring of the microbiota within UK families

E Nikolaou, EL German, A Howard, HM Nabwera… - Scientific Reports, 2023 - nature.com
Monitoring the presence of commensal and pathogenic respiratory microorganisms is of
critical global importance. However, community-based surveillance is difficult because …

[HTML][HTML] Effect of age and season on respiratory mucosal immune marker profiles

E van Woudenbergh, DM van Rooijen… - Journal of Allergy and …, 2024 - Elsevier
Background The upper respiratory tract is continuously exposed to microorganisms and
noxious elements, leading to local immune responses and the secretion of immune markers …

Household air pollution and pneumococcal density related to nasopharyngeal inflammation in mothers and children in Ethiopia: A cross-sectional study

H Olsson, M Tamire, E Samuelsson, A Addissie… - Plos one, 2024 - journals.plos.org
Background Three billion people in low-and middle-income countries are exposed to
household air pollution as they use biomass fuel for cooking. We investigated the …