Systematic review of mutations associated with resistance to the new and repurposed Mycobacterium tuberculosis drugs bedaquiline, clofazimine, linezolid …
Background Improved genetic understanding of Mycobacterium tuberculosis (MTB)
resistance to novel and repurposed anti-tubercular agents can aid the development of rapid …
resistance to novel and repurposed anti-tubercular agents can aid the development of rapid …
Whole genome sequencing of Mycobacterium tuberculosis: current standards and open issues
Whole genome sequencing (WGS) of Mycobacterium tuberculosis has rapidly progressed
from a research tool to a clinical application for the diagnosis and management of …
from a research tool to a clinical application for the diagnosis and management of …
CARD 2020: antibiotic resistome surveillance with the comprehensive antibiotic resistance database
Abstract The Comprehensive Antibiotic Resistance Database (CARD; https://card. mcmaster.
ca) is a curated resource providing reference DNA and protein sequences, detection models …
ca) is a curated resource providing reference DNA and protein sequences, detection models …
CARD 2023: expanded curation, support for machine learning, and resistome prediction at the Comprehensive Antibiotic Resistance Database
Abstract The Comprehensive Antibiotic Resistance Database (CARD; card. mcmaster. ca)
combines the Antibiotic Resistance Ontology (ARO) with curated AMR gene (ARG) …
combines the Antibiotic Resistance Ontology (ARO) with curated AMR gene (ARG) …
Integrating informatics tools and portable sequencing technology for rapid detection of resistance to anti-tuberculous drugs
Background Mycobacterium tuberculosis resistance to anti-tuberculosis drugs is a major
threat to global public health. Whole genome sequencing (WGS) is rapidly gaining traction …
threat to global public health. Whole genome sequencing (WGS) is rapidly gaining traction …
Population structure, biogeography and transmissibility of Mycobacterium tuberculosis
L Freschi, R Vargas Jr, A Husain, SMM Kamal… - Nature …, 2021 - nature.com
Mycobacterium tuberculosis is a clonal pathogen proposed to have co-evolved with its
human host for millennia, yet our understanding of its genomic diversity and biogeography …
human host for millennia, yet our understanding of its genomic diversity and biogeography …
Regimens to treat multidrug-resistant tuberculosis: past, present and future perspectives
E Pontali, MC Raviglione… - European Respiratory …, 2019 - Eur Respiratory Soc
Over the past few decades, treatment of multidrug-resistant (MDR)/extensively drug-resistant
(XDR) tuberculosis (TB) has been challenging because of its prolonged duration (up to 20 …
(XDR) tuberculosis (TB) has been challenging because of its prolonged duration (up to 20 …
The Lancet Respiratory Medicine Commission: 2019 update: epidemiology, pathogenesis, transmission, diagnosis, and management of multidrug-resistant and …
Summary The Lancet Respiratory Medicine Commission on drug-resistant tuberculosis was
published in 2017, which comprehensively reviewed and provided recommendations on …
published in 2017, which comprehensively reviewed and provided recommendations on …
A convolutional neural network highlights mutations relevant to antimicrobial resistance in Mycobacterium tuberculosis
AG Green, CH Yoon, ML Chen, Y Ektefaie… - Nature …, 2022 - nature.com
Long diagnostic wait times hinder international efforts to address antibiotic resistance in M.
tuberculosis. Pathogen whole genome sequencing, coupled with statistical and machine …
tuberculosis. Pathogen whole genome sequencing, coupled with statistical and machine …
The MAGMA pipeline for comprehensive genomic analyses of clinical Mycobacterium tuberculosis samples
TH Heupink, L Verboven, A Sharma… - PLoS Computational …, 2023 - journals.plos.org
Background Whole genome sequencing (WGS) holds great potential for the management
and control of tuberculosis. Accurate analysis of samples with low mycobacterial burden …
and control of tuberculosis. Accurate analysis of samples with low mycobacterial burden …