From our daily nutrition and synthesis within cells, nucleosides enter the bloodstream and
circulate throughout the body and tissues. Nucleosides and nucleotides are classically …

Colorectal cancer (CRC) is one of the most life‐threatening neoplasias in terms of incidence
and mortality worldwide. Vitamin D deficiency has been associated with an increased risk of …

Polyphenols are chemopreventive through the induction of nuclear factor erythroid 2 related
factor 2 (Nrf2)-mediated proteins and anti-inflammatory pathways. These pathways …

Dietary nutrients regulate intestinal homeostasis through a variety of complex mechanisms,
to affect the host health. Nowadays, various models have been used to investigate the …

UPP1, a crucial pyrimidine metabolism-related enzyme, catalyzes the reversible
phosphorylation of uridine to uracil and ribose-1-phosphate. However, the effects of UPP1 in …

Colorectal cancer (CRC) is commonly associated with aberrant transcription regulation, but
characteristics of the dysregulated transcription factors in CRC pathogenesis remain to be …

The complexity of the tumor microenvironment (TME) is a crucial factor in lung
adenocarcinoma (LUAD) progression. To gain deeper insights into molecular mechanisms …

Recent epidemiological and preclinical evidence indicates that vitamin D3 inhibits colorectal
cancer (CRC) progression, but the mechanism has not been completely elucidated. This …

Active vitamin D, 1α, 25 (OH) 2D3, is a nuclear hormone with roles in colonic homeostasis
and carcinogenesis; yet, mechanisms underlying these effects are incompletely understood …

Tobacco smoke and red/processed meats are well-known risk factors for colorectal cancer
(CRC). Most research has focused on studies of normal colon biopsies in epidemiologic …