Crosstalk between ER stress, autophagy and inflammation
S Chipurupalli, U Samavedam, N Robinson - Frontiers in Medicine, 2021 - frontiersin.org
The endoplasmic reticulum (ER) is not only responsible for protein synthesis and folding but
also plays a critical role in sensing cellular stress and maintaining cellular homeostasis …
also plays a critical role in sensing cellular stress and maintaining cellular homeostasis …
Innate and adaptive immunity in inflammatory bowel disease
A Geremia, P Biancheri, P Allan, GR Corazza… - Autoimmunity …, 2014 - Elsevier
Inflammatory bowel disease (IBD) includes Crohn's disease (CD) and ulcerative colitis (UC).
The exact cause of IBD remains unknown. Available evidence suggests that an abnormal …
The exact cause of IBD remains unknown. Available evidence suggests that an abnormal …
Inflammatory bowel disease: cause and immunobiology
DC Baumgart, SR Carding - The Lancet, 2007 - thelancet.com
Crohn's disease and ulcerative colitis are idiopathic inflammatory bowel disorders. In this
paper, we discuss how environmental factors (eg, geography, cigarette smoking, sanitation …
paper, we discuss how environmental factors (eg, geography, cigarette smoking, sanitation …
[HTML][HTML] XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease
Inflammatory bowel disease (IBD) has been attributed to aberrant mucosal immunity to the
intestinal microbiota. The transcription factor XBP1, a key component of the endoplasmic …
intestinal microbiota. The transcription factor XBP1, a key component of the endoplasmic …
A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1
We performed a genome-wide association study of 19,779 nonsynonymous SNPs in 735
individuals with Crohn disease and 368 controls. A total of 7,159 of these SNPs were …
individuals with Crohn disease and 368 controls. A total of 7,159 of these SNPs were …
[HTML][HTML] ER stress-induced inflammation: does it aid or impede disease progression?
Different lines of research have revealed that pathways activated by the endoplasmic
reticulum (ER) stress response induce sterile inflammation. When activated, all three …
reticulum (ER) stress response induce sterile inflammation. When activated, all three …
Differential alteration in intestinal epithelial cell expression of toll-like receptor 3 (TLR3) and TLR4 in inflammatory bowel disease
E Cario, DK Podolsky - Infection and immunity, 2000 - Am Soc Microbiol
Initiation and perpetuation of the inflammatory intestinal responses in inflammatory bowel
disease (IBD) may result from an exaggerated host defense reaction of the intestinal …
disease (IBD) may result from an exaggerated host defense reaction of the intestinal …
Endoplasmic reticulum stress in immunity
SE Bettigole, LH Glimcher - Annual review of immunology, 2015 - annualreviews.org
Immune responses occur in the midst of a variety of cellular stresses that can severely
perturb endoplasmic reticulum (ER) function. The unfolded protein response is a three …
perturb endoplasmic reticulum (ER) function. The unfolded protein response is a three …
Clinical aspects and pathophysiology of inflammatory bowel disease
BA Hendrickson, R Gokhale… - Clinical microbiology …, 2002 - Am Soc Microbiol
The chronic inflammatory bowel diseases (IBD), Crohn's disease and ulcerative colitis, are
recognized as important causes of gastrointestinal disease in children and adults. In this …
recognized as important causes of gastrointestinal disease in children and adults. In this …
Defining the role of the MHC in autoimmunity: a review and pooled analysis
MMA Fernando, CR Stevens, EC Walsh… - PLoS …, 2008 - journals.plos.org
The major histocompatibility complex (MHC) is one of the most extensively studied regions
in the human genome because of the association of variants at this locus with autoimmune …
in the human genome because of the association of variants at this locus with autoimmune …