Mesenchymal stem cells/marrow stromal cells (MSCs) present a promising tool for cell
therapy, and are currently being tested in US FDA-approved clinical trials for myocardial …

Overwhelming evidence collected since the early 1990's strongly supports the notion that
BDNF is among the key regulators of synaptic plasticity in many areas of the mammalian …

Huntington's disease (HD) is a fatal degenerative autosomal dominant neuropsychiatric
disease that causes neuronal death and is characterized by progressive striatal and then …

Enhancement of brain-derived neurotrophic factor (BDNF) signalling has great potential in
therapy for neurological and psychiatric disorders. This neurotrophin not only attenuates cell …

Neurodegenerative diseases are a major burden for our society, affecting millions of people
worldwide. A main goal of past and current research is to enhance our understanding of the …

Background Neurons extend their dendrites and axons to build functional neural circuits,
which are regulated by both positive and negative signals during development. Brain …

Huntington's disease (HD) is a dominantly inherited neurodegenerative disease caused by
an increase in CAG repeats in the Huntingtin gene (HTT). The striatum is one of the most …

Abstract Changes in the level and activity of brain-derived neurotrophic factor (BDNF) have
been described in a number of neurodegenerative disorders since early 1990s. However …

Dementia encapsulates a set of symptoms that include loss of mental abilities such as
memory, problem solving or language, and reduces a person's ability to perform daily …

proBDNF, a precursor of brain-derived neurotrophic factor (BDNF), is anterogradely
transported and released from nerve terminals, but the mechanism underlying this process …