Conspectus What we can call a molecular robot is a set of molecular devices such as
sensors, logic gates, and actuators integrated into a consistent system. The molecular robot …

Within the last decade, it has become obvious that RNA plays an important role in regulating
gene expression. This has led to a plethora of approaches aiming at exploiting the …

Regulated transgene expression is an integral component of gene therapies, cell therapies
and biomanufacturing. However, transcription factor-based regulation, upon which most …

MicroRNAs (miRNA or miR) are short noncoding RNA of about 21–23 nucleotides that play
critical roles in multiple aspects of biological processes by mediating translational …

Recent advancements in molecular robotics have been greatly contributed by the progress
in various fields of science and technology, particularly in supramolecular chemistry, bio-and …

Synthetic gene switches are basic building blocks for the construction of complex gene
circuits that transform mammalian cells into useful cell-based machines for next-generation …

The bottom-up assembly of biological components in synthetic biology has contributed to a
better understanding of natural phenomena and the development of new technologies for …

Translational modulation based on RNA-binding proteins can be used to construct artificial
gene circuits, but RNA-binding proteins capable of regulating translation efficiently and …

Synthetic biology has great potential for future therapeutic applications including
autonomous cell programming through the detection of protein signals and the production of …

Highlights•Overview of RNA-based switches for mammalian gene control.•Design principles
of aptamer-and aptazyme-based.•Advantages and applications of RNA-based …