Pathogenesis of osteoarthritis: risk factors, regulatory pathways in chondrocytes, and experimental models

Y He, Z Li, PG Alexander, BD Ocasio-Nieves, L Yocum… - Biology, 2020 - mdpi.com
As the most common chronic degenerative joint disease, osteoarthritis (OA) is the leading
cause of pain and physical disability, affecting millions of people worldwide. Mainly …

Mechanisms of osteoarthritic pain. Studies in humans and experimental models

A Eitner, GO Hofmann, HG Schaible - Frontiers in molecular …, 2017 - frontiersin.org
Pain due to osteoarthritis (OA) is one of the most frequent causes of chronic pain. However,
the mechanisms of OA pain are poorly understood. This review addresses the mechanisms …

Animal models of osteoarthritis: challenges of model selection and analysis

E Teeple, GD Jay, KA Elsaid, BC Fleming - The AAPS journal, 2013 - Springer
Osteoarthritis (OA) is the most common musculoskeletal disease, affecting millions of
individuals worldwide. New treatment approaches require an understanding of the …

Mouse models of osteoarthritis: modelling risk factors and assessing outcomes

H Fang, F Beier - Nature Reviews Rheumatology, 2014 - nature.com
Osteoarthritis (OA) is a prevalent musculoskeletal disease that results in pain and low quality
of life for patients, as well as enormous medical and socioeconomic burdens. The molecular …

Animal models of temporomandibular joint osteoarthritis: classification and selection

Y Zhao, Y An, L Zhou, F Wu, G Wu, J Wang… - Frontiers in …, 2022 - frontiersin.org
Temporomandibular joint osteoarthritis (TMJOA) is a common degenerative joint disease
that can cause severe pain and dysfunction. It has a serious impact on the quality of lives of …

Alteration of sensory neurons and spinal response to an experimental osteoarthritis pain model

HJ Im, JS Kim, X Li, N Kotwal, DR Sumner… - Arthritis & …, 2010 - Wiley Online Library
Objective To verify the biologic links between progressive cellular and structural alterations
within knee joint components and development of symptomatic chronic pain that are …

[HTML][HTML] What constitutes an “animal model of osteoarthritis”–the need for consensus?

CB Little, S Zaki - Osteoarthritis and cartilage, 2012 - Elsevier
OBJECTIVE: To review the use of animal models of osteoarthritis (OA) with regard to their
utility for investigation of the mechanisms and regulation of structural pathology and pain …

Therapeutic and nutraceutical potentials of a brown seaweed Sargassum fusiforme

J Liu, S Luthuli, Y Yang, Y Cheng… - Food Science & …, 2020 - Wiley Online Library
Sargassum fusiforme, also known as Yangqicai (羊栖菜) in Chinese and Hijiki in Japanese,
is a brown seaweed that grows abundantly along the rocky coastlines of Asian countries …

Autonomic nervous system dysregulation and osteoarthritis pain: mechanisms, measurement, and future outlook

TD Yeater, CJ Cruz, Y Cruz-Almeida… - Current rheumatology …, 2022 - Springer
Abstract Purpose of Review The autonomic nervous system is an important regulator of
stress responses and exhibits functional changes in chronic pain states. This review …

[HTML][HTML] OA foundations–experimental models of osteoarthritis

S Zaki, CL Blaker, CB Little - Osteoarthritis and Cartilage, 2022 - Elsevier
Osteoarthritis (OA) is increasingly recognised as a disease of diverse phenotypes with
variable clinical presentation, progression, and response to therapeutic intervention. This …