Background Severe trauma represents a major global public health burden and the
management of post-traumatic bleeding continues to challenge healthcare systems around …

Viscoelastic testing (VET), including thromboelastography and thromboelastometry,
provides a rapid and comprehensive picture of whole blood coagulation dynamics and …

The transmembrane P-glycoprotein (P-gp) pumps that efflux drugs are a major mechanism
of cancer drug resistance. They are also important in protecting normal tissue cells from …

POC SCTs are not able to characterise the complexity of trauma-associated coagulopathy.
VETs provide a rapid estimation of underlying haemostatic disorders, thereby providing …

The concept of intensive care units (ICU) has existed for almost 70 years, with outstanding
development progress in the last decades. Multidisciplinary care of critically ill patients has …

This narrative review explores the pathophysiology, geographic variation, and historical
developments underlying the selection of fixed ratio versus whole blood resuscitation for …

Modern approaches to resuscitation seek to bring patient interventions as close as possible
to the initial trauma. In recent decades, fresh or cold-stored whole blood has gained …

For decades, the need for a change in perioperative coagulation management had been
growing. A proactive attitude, including frequent assessment and reassessment of bleeding …

Objectives Detailed and decisive information about the patients' coagulation status is
important in various emergency situations. Conventional global coagulation testing …

Haemorrhagic shock is the most common preventable cause of early mortality in polytrauma
patients. Road traffic injuries are the most common cause for polytrauma and most …