The incretin hormones glucose‐dependent insulinotropic polypeptide (GIP) and glucagon‐
like peptide‐1 (GLP‐1) have their main physiological role in augmenting insulin secretion …

Insulin and glucagon exert opposing effects on glucose metabolism and, consequently,
pancreatic islet β-cells and α-cells are considered functional antagonists. The intra-islet …

Incretin hormones are gut peptides that are secreted after nutrient intake and stimulate
insulin secretion together with hyperglycaemia. GIP (glucose‐dependent insulinotropic …

The risk of fragility fractures is increased in patients with either type 1 diabetes mellitus
(T1DM) or type 2 diabetes mellitus (T2DM). Although BMD is decreased in T1DM, BMD in …

abstract Incretin hormones (glucose-dependent insulinotropic polypeptide [GIP] and
glucagon-like peptide-1 [GLP-1]) play a role in the pathophysiology of type 2 diabetes. Along …

In healthy individuals, the incretin hormone glucagon-like peptide 1 (GLP1) potentiates
insulin release and suppresses glucagon secretion in response to the ingestion of nutrients …

Gut hormones orchestrate pivotal physiological processes in multiple metabolically active
tissues, including the pancreas, liver, adipose tissue, gut and central nervous system …

The incretin effect describes the phenomenon whereby oral glucose elicits higher insulin
secretory responses than does intravenous glucose, despite inducing similar levels of …

The gastrointestinal tract—the largest endocrine network in human physiology—
orchestrates signals from the external environment to maintain neural and hormonal control …

Unimolecular dual incretins derived from hybridized glucagon-like peptide 1 (GLP-1) and
glucose-dependent insulinotropic peptide (GIP) sequences have demonstrated synergistic …