Maintenance of protein homeostasis and organelle integrity and function is critical for
cellular homeostasis and cell viability. Autophagy is the principal mechanism that mediates …

To coordinate, adapt and respond to biological signals, cells convey specific messages to
other cells. An important aspect of cell–cell communication involves secretion of molecules …

Macroautophagy and microautophagy are highly conserved eukaryotic cellular processes
that degrade cytoplasmic material in lysosomes. Both pathways involve characteristic …

Exosomes are specialized cargo delivery vesicles secreted from cells by fusion of
multivesicular bodies (MVBs) with the plasma membrane (PM). While the function of …

Mitochondrial quality control is critical for cardiac homeostasis as these organelles are
responsible for generating most of the energy needed to sustain contraction. Dysfunctional …

Lysosomes are catabolic organelles that govern numerous cellular processes, including
macromolecule degradation, nutrient signalling and ion homeostasis. Aberrant changes in …

The extracellular vesicle (EV) surface corona is emerging as a crucial mediator of EV
functions. This Comment discusses the roles and biogenesis of the EV corona, as well as …

Multiple sclerosis (MS) is a chronic progressive demyelinating disease of the central
nervous system (CNS) due to an increase of abnormal peripherally auto-reactive T …

ATG5 is a part of the E3 ligase directing lipidation of ATG8 proteins, a process central to
membrane atg8ylation and canonical autophagy. Loss of Atg5 in myeloid cells causes early …

Exosomes are small vesicles that are secreted from cells to dispose of undegraded
materials and mediate intercellular communication. A major source of exosomes is …