While the monoamine deficiency hypothesis of depression is still most commonly used to
explain the actions of antidepressant drugs, a growing body of evidence has accumulated …

Mecamylamine (Inversine®), the first orally available antihypertensive agent launched in the
1950s, is rarely used today for hypertension because of its widespread ganglionic side …

There is widespread involvement of purinergic signalling in endocrine biology. Pituitary cells
express P1, P2X and P2Y receptor subtypes to mediate hormone release. Adenosine 5 …

For decades, ibogaine─ the main psychoactive alkaloid found in Tabernanthe iboga─ has
been investigated as a possible treatment for substance use disorders (SUDs) due to its …

Neuronal nicotinic acetylcholine receptors of chromaffin cells in the adrenal medulla are
physiologically activated by acetylcholine to mediate catecholamine release into the …

We have applied pharmacological magnetic resonance imaging (phMRI) methods to map
the functional response to nicotine in drug-naïve rats. Nicotine (0.35 mg/kg intravenous (iv)) …

Chemokines and ATP are among the mediators of inflammatory sites that can enter the
circulation via damaged blood vessels. The main function of chemokines is leukocyte …

We generated a mouse line harboring an autosomal-dominant nocturnal frontal lobe
epilepsy (ADNFLE) mutation: the α4 nicotinic receptor S248F knock-in strain. In this mouse …

Background and Purpose Progressive dysfunction of cholinergic transmission is a well‐
known characteristic of Alzheimer's disease (AD). Amyloid β (Aβ) peptide oligomers are …

Background The cholinergic anti-inflammatory pathway is an endogenous mechanism by
which the autonomic nervous system attenuates macrophage activation via nicotinic …