Structure-activity relationship (SAR) study and design strategies of nitrogen-containing heterocyclic moieties for their anticancer activities

J Akhtar, AA Khan, Z Ali, R Haider, MS Yar - European journal of medicinal …, 2017 - Elsevier
The present review article offers a detailed account of the design strategies employed for the
synthesis of nitrogen-containing anticancer agents. The results of different studies describe …

Recent advance in oxazole-based medicinal chemistry

HZ Zhang, ZL Zhao, CH Zhou - European journal of medicinal chemistry, 2018 - Elsevier
Oxazole compounds containing nitrogen and oxygen atoms in the five-membered aromatic
ring are readily able to bind with a variety of enzymes and receptors in biological systems …

Antimicrobial activity of 1, 3, 4-oxadiazole derivatives

T Glomb, P Świątek - International journal of molecular sciences, 2021 - mdpi.com
The worldwide development of antimicrobial resistance forces scientists to search for new
compounds to which microbes would be sensitive. Many new structures contain the 1, 3, 4 …

Anti-cancer activity of derivatives of 1, 3, 4-oxadiazole

T Glomb, K Szymankiewicz, P Świątek - Molecules, 2018 - mdpi.com
Compounds containing 1, 3, 4-oxadiazole ring in their structure are characterised by
multidirectional biological activity. Their anti-proliferative effects associated with various …

Expedition of sulfur‐containing heterocyclic derivatives as cytotoxic agents in medicinal chemistry: A decade update

K Laxmikeshav, P Kumari… - Medicinal Research …, 2022 - Wiley Online Library
This review article proposes a comprehensive report of the design strategies engaged in the
development of various sulfur‐bearing cytotoxic agents. The outcomes of various studies …

Cytotoxic properties of 1, 3, 4-thiadiazole derivatives—A review

S Janowska, A Paneth, M Wujec - Molecules, 2020 - mdpi.com
During recent years, small molecules containing five-member heterocyclic moieties have
become the subject of considerable growing interest for designing new antitumor agents …

[PDF][PDF] Crystal structure and Hirshfeld surface analysis of ethyl (3E)-5-(4-chlorophenyl)-3-{[(4-chlorophenyl) formamido] imino}-7-methyl-2H, 3H, 5H-[1, 3] thiazolo [3, 2 …

SK Mohamed, JT Mague, M Akkurt… - Acta …, 2022 - journals.iucr.org
In the title molecule, C23H20Cl2N4O3S, the thiazole ring is planar while the pyrimidine unit
fused to it adopts a screw-boat conformation. In the crystal, thick sheets parallel to the bc …

Determination of potential inhibitors based on isatin derivatives against SARS-CoV-2 main protease (mpro): a molecular docking, molecular dynamics and structure …

VN Badavath, A Kumar, PK Samanta… - Journal of …, 2022 - Taylor & Francis
Abstract SARS-COV-2, the novel coronavirus and root of global pandemic COVID-19
caused a severe health threat throughout the world. Lack of specific treatments raised an …

A review exploring therapeutic worth of 1, 3, 4-oxadiazole tailored compounds

G Verma, MF Khan, W Akhtar, MM Alam… - Mini Reviews in …, 2019 - ingentaconnect.com
1, 3, 4-Oxadiazole, a five-membered aromatic ring can be seen in a number of synthetic
molecules. The peculiar structural feature of 1, 3, 4-oxadiazole ring with pyridine type of …

Synthesis and anticancer activity of new ((Furan-2-yl)-1, 3, 4-thiadiazolyl)-1, 3, 4-oxadiazole acyclic sugar derivatives

AF Kassem, IF Nassar, MT Abdel-Aal… - Chemical and …, 2019 - jstage.jst.go.jp
New sugar hydrazones incorporating furan and/or 1, 3, 4-thiadiazole ring systems were
synthesized by reaction of the corresponding hydrazide with different aldose sugars …