The vascular blood–brain barrier is a highly regulated interface between the blood and
brain. Its primary function is to protect central neurons while signaling the presence of …

Therapies directed toward the central nervous system remain difficult to translate into
improved clinical outcomes. This is largely due to the blood–brain barrier (BBB), arguably …

Brain fluids are rigidly regulated to provide stable environments for neuronal function, eg,
low K+, Ca 2+, and protein to optimise signalling and minimise neurotoxicity. At the same …

Worldwide, over 694 million people have been infected with SARS-CoV-2, with an estimated
55–60% of those infected developing COVID-19. Since the beginning of the pandemic in …

The vascular basement membrane contributes to the integrity of the blood-brain barrier
(BBB), which is formed by brain capillary endothelial cells (BCECs). The BCECs receive …

Alzheimer's disease (AD) is a chronic neurodegenerative disorder characterized by the
pathological accumulation of amyloid beta (Aβ) peptides and neurofibrillary tangles …

Although dormancy is thought to play a key role in the metastasis of breast tumor cells to the
brain, our knowledge of the molecular mechanisms regulating disseminated tumor cell …

Brain capillary endothelial cells form the blood-brain barrier (BBB), which is covered with
basement membranes and is also surrounded by pericytes and astrocyte end-feet in the …

To maintain the homeostatic environment required for proper function of central nervous
system (CNS) neurons the endothelial cells of CNS microvessels tightly regulate the …

Malignant gliomas are devastating tumours that frequently kill patients within 1 year of
diagnosis. The major obstacle to a cure is diffuse invasion, which enables tumours to …